1,4-Piperazinedicarboxylic acid, 2-(aminocarbonyl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester

Base Information

• Chemical Name: 1,4-Piperazinedicarboxylic acid, 2-(aminocarbonyl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester
• CAS No.: 569348-20-5
• Molecular Formula: C18H25N3O5
• Molecular Weight: 363.414
• Mol file: 569348-20-5.mol

Synonyms:

Chemical Property of 1,4-Piperazinedicarboxylic acid, 2-(aminocarbonyl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-Piperazinedicarboxylic acid, 2-(aminocarbonyl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester

There total 1 articles about 1,4-Piperazinedicarboxylic acid, 2-(aminocarbonyl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-((benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (149057-19-2) → 4-benzyl 1-(tert-butyl) 2-carbamoylpiperazine-1,4-dicarboxylate (569348-20-5)

Guidance literature:

4-[(benzyloxy)carbonyl]-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid; With triethylamine; methyl chloroformate; In dichloromethane; at -30 - 0 ℃; Inert atmosphere;

With ammonia; In dichloromethane; at -30 - 20 ℃; for 16.5h;

Reference yield:

4-benzyl 1-(tert-butyl) 2-carbamoylpiperazine-1,4-dicarboxylate (569348-20-5) → 4-benzyl 1-(tert-butyl) 2-(aminomethyl)piperazine-1,4-dicarboxylate (1202800-72-3)

Guidance literature:

4-benzyl 1-(tert-butyl) 2-carbamoylpiperazine-1,4-dicarboxylate; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With methanol; In tetrahydrofuran; at 20 ℃;

Reference yield:

4-benzyl 1-(tert-butyl) 2-carbamoylpiperazine-1,4-dicarboxylate (569348-20-5) → 4-benzyl 1-(tert-butyl) 2-cyanopiperazine-1,4-dicarboxylate

Guidance literature:

With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; at 20 ℃; for 2h;

upstream raw materials:

4-((benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

Downstream raw materials:

4-benzyl 1-(tert-butyl) 2-(aminomethyl)piperazine-1,4-dicarboxylate

Refernces

• 1、 -. "DIKETO AZOLOPIPERIDINES AND AZOLOPIPERAZINES AS ANTI-HIV AGENTS". Page/Page column 109; 112. . Retrieved 2010/01/30.