N'-[5-(4-CHLOROBENZOYL)-1,3-THIAZOL-2-YL]-N,N-DIMETHYLIMINOFORMAMIDE

Base Information

• Chemical Name: N'-[5-(4-CHLOROBENZOYL)-1,3-THIAZOL-2-YL]-N,N-DIMETHYLIMINOFORMAMIDE
• CAS No.: 569350-52-3
• Molecular Formula: C13H12ClN3OS
• Molecular Weight: 293.777
• Mol file: 569350-52-3.mol

Synonyms:N'-[5-(4-CHLOROBENZOYL)-1,3-THIAZOL-2-YL]-N,N-DIMETHYLIMINOFORMAMIDE;N'-[5-(4-chlorobenzoyl)-1,3-thiazol-2-yl]-N,N-dimethylformamidine;N'-[5-(4-chlorobenzoyl)-1,3-thiazol-2-yl]-N,N-dimethylimidoformamide;

Chemical Property of N'-[5-(4-CHLOROBENZOYL)-1,3-THIAZOL-2-YL]-N,N-DIMETHYLIMINOFORMAMIDE

Chemical Property:

• PSA: 73.80000
• LogP: 3.24890

Purity/Quality:

N'-[5-(4-Chlorobenzoyl)-1,3-thiazol-2-yl]-N,N-dimethyliminoformamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N'-[5-(4-CHLOROBENZOYL)-1,3-THIAZOL-2-YL]-N,N-DIMETHYLIMINOFORMAMIDE

There total 1 articles about N'-[5-(4-CHLOROBENZOYL)-1,3-THIAZOL-2-YL]-N,N-DIMETHYLIMINOFORMAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-chlorobenzoylmethyl bromide (536-38-9) + 1,3-Bis-[1-dimethylamino-meth-(E)-ylidene]-thiourea (121876-98-0) → N'-[5-(4-chlorobenzoyl)-1,3-thiazol-2-yl]-N,N-dimethylimidoformamide (569350-52-3)

Guidance literature:

4-chlorobenzoylmethyl bromide; 1,3-Bis-[1-dimethylamino-meth-(E)-ylidene]-thiourea; In dichloromethane; at 20 ℃; for 0.25h;

With triethylamine; In dichloromethane; for 20h;

DOI:10.1021/jo034381l

Reference yield: 86.0%

3-chloro-3-oxopropanoic acid methyl ester (37517-81-0) + N'-[5-(4-chlorobenzoyl)-1,3-thiazol-2-yl]-N,N-dimethylimidoformamide (569350-52-3) → 2-(4-chloro-benzoyl)-5-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid methyl ester

Guidance literature:

3-chloro-3-oxopropanoic acid methyl ester; N'-[5-(4-chlorobenzoyl)-1,3-thiazol-2-yl]-N,N-dimethylimidoformamide; In dichloromethane; at 20 ℃; for 4h;

With triethylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jo034381l

Reference yield: 82.0%

4-(bromoacetyl)toluene (619-41-0) + N'-[5-(4-chlorobenzoyl)-1,3-thiazol-2-yl]-N,N-dimethylimidoformamide (569350-52-3) → 2-(4-chlorobenzoyl)-5-(4-methylbenzoyl)imidazo[2,1-b][1,3]thiazole

Guidance literature:

4-(bromoacetyl)toluene; N'-[5-(4-chlorobenzoyl)-1,3-thiazol-2-yl]-N,N-dimethylimidoformamide; In tetrahydrofuran; Heating;

With triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1021/jo034381l

upstream raw materials:

4-chlorobenzoylmethyl bromide

1,3-Bis-[1-dimethylamino-meth-(E)-ylidene]-thiourea

Downstream raw materials:

3-(p-chlorobenzoyl)-5-(1,2-O-isopropylidene-3-O-p-methoxybenzyl-α-D-xylofuranos-5-ulo-5-yl)imidazo[2,1-b]thiazole

3-(p-chlorobenzoyl)-5-(1,2-O-isopropylidene-3-O-tert-butyldimethylsilyl-α-D-xylofuranos-5-ulo-5-yl)imidazo[2,1-b]thiazole

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