2H-Isoindole-2-carboxylic acid, 1-[2-[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-[1-methyl-4-(2-methylpropyl)- 4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-oxoethyl]-1,3-dihydro-, 1,1-dimethylethyl ester

Base Information

Chemical Name:2H-Isoindole-2-carboxylic acid, 1-[2-[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-[1-methyl-4-(2-methylpropyl)- 4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-oxoethyl]-1,3-dihydro-, 1,1-dimethylethyl ester
CAS No.:569653-82-3
Molecular Formula:C₃₈H₅₄ClN₅O₄
Molecular Weight:680.331
Hs Code.:

2H-Isoindole-2-carboxylic acid,
1-[2-[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-[1-methyl-4-(2-methylpropyl)-
4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-oxoethyl]-1,3-dihydro-,
1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 2H-Isoindole-2-carboxylic acid, 1-[2-[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-[1-methyl-4-(2-methylpropyl)- 4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-oxoethyl]-1,3-dihydro-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2H-Isoindole-2-carboxylic acid, 1-[2-[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-[1-methyl-4-(2-methylpropyl)- 4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-oxoethyl]-1,3-dihydro-, 1,1-dimethylethyl ester

There total 4 articles about 2H-Isoindole-2-carboxylic acid, 1-[2-[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-[1-methyl-4-(2-methylpropyl)- 4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-oxoethyl]-1,3-dihydro-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 578707-19-4
4-(4-cyano-1-methyl-piperidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 569653-82-3
1-({1-(4-chloro-benzyl)-2-[4-(4-isobutyl-1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-methyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / 40 °C

2: TFA / CH₂Cl₂

3: HATU; DIEA / CH₂Cl₂

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2006.04.016

Reference yield:

: 903891-01-0
4-(4-isobutyl-1-methyl-piperidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 569653-82-3
1-({1-(4-chloro-benzyl)-2-[4-(4-isobutyl-1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-methyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂

2: HATU; DIEA / CH₂Cl₂

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane;
DOI:10.1016/j.bmcl.2006.04.016

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 569653-82-3
1-({1-(4-chloro-benzyl)-2-[4-(4-isobutyl-1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-methyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: ZnI₂

2: tetrahydrofuran; diethyl ether / 40 °C

3: TFA / CH₂Cl₂

4: HATU; DIEA / CH₂Cl₂

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; zinc(II) iodide; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Strecker synthesis;
DOI:10.1016/j.bmcl.2006.04.016