Diethyl 2-acetamido-2-(3-oxo-3-phenylpropyl)malonate

Base Information

Chemical Name:Diethyl 2-acetamido-2-(3-oxo-3-phenylpropyl)malonate
CAS No.:2847-91-8
Molecular Formula:C18H23 N O6
Molecular Weight:349.3783
Hs Code.:
NSC Number:29456

Synonyms:Diethyl 2-acetamido-2-(3-oxo-3-phenylpropyl)malonate;2847-91-8;NSC29456;NSC-29456;AKOS024324760;A819468

Suppliers and Price of Diethyl 2-acetamido-2-(3-oxo-3-phenylpropyl)malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Diethyl 2-acetamido-2-(3-oxo-3-phenylpropyl)malonate

Chemical Property:

Vapor Pressure:9.51E-12mmHg at 25°C
Boiling Point:540.5°Cat760mmHg
Flash Point:280.7°C
Density:1.168g/cm³
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:349.15253745
Heavy Atom Count:25
Complexity:478

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(CCC(=O)C1=CC=CC=C1)(C(=O)OCC)NC(=O)C

Technology Process of Diethyl 2-acetamido-2-(3-oxo-3-phenylpropyl)malonate

There total 2 articles about Diethyl 2-acetamido-2-(3-oxo-3-phenylpropyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 29636-75-7
3-bromo-1-phenylpropan-1-one

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 2847-91-8
4-acetamido-4,4-diethoxycarbonyl-1-phenylbutan-1-one

Guidance literature:: With sodium ethanolate; In ethanol; for 18h; Heating;

Reference yield:

: 2847-91-8
4-acetamido-4,4-diethoxycarbonyl-1-phenylbutan-1-one

Guidance literature:: β-Chlorpropiophenon, Acetamidomalonsaeurediethylester;
DOI:10.1021/jm00223a020

Reference yield:

: 2847-91-8
4-acetamido-4,4-diethoxycarbonyl-1-phenylbutan-1-one

: 111836-37-4
1,4-imino-1-methoxycarbonyl-exo-2,3-(N-methyldicarboximido)-4-phenylcyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1: 6 N aq. HCl / 18 h / Heating

2: H₂SO₄ conc. / 3 h / Heating

3: 60 percent / toluene / 48 h / 130 °C

With hydrogenchloride; sulfuric acid; In toluene;