3-Methyl-2-naphthylamine

Base Information

• Chemical Name: 3-Methyl-2-naphthylamine
• CAS No.: 10546-24-4
• Molecular Formula: C11H11 N
• Molecular Weight: 157.215
• NSC Number: 136515
• UNII: 24TD1NM2XL
• DSSTox Substance ID: DTXSID40147140
• Nikkaji Number: J34.581D
• Wikidata: Q26840786
• ChEMBL ID: CHEMBL84042
• Mol file: 10546-24-4.mol

Synonyms:3-methyl-2-naphthylamine;3-methyl-2-naphthylamine hydrochloride

Chemical Property of 3-Methyl-2-naphthylamine

Chemical Property:

• Vapor Pressure: 0.000366mmHg at 25°C
• Melting Point: 135.25°C
• Refractive Index: 1.6722 (estimate)
• Boiling Point: 318.2°C at 760 mmHg
• Flash Point: 161.6°C
• PSA: 26.02000
• Density: 1.106g/cm³
• LogP: 3.31160
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 157.089149355
• Heavy Atom Count: 12
• Complexity: 155

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-METHYL-2-NAPHTHYLAMINE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=CC=CC=C2C=C1N

Technology Process of 3-Methyl-2-naphthylamine

There total 10 articles about 3-Methyl-2-naphthylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-Amino-3-naphthoic acid (5959-52-4) → 3-methylnaphthalene-2-amine (10546-24-4)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In xylene; at 150 ℃; for 24h;

DOI:10.1002/adsc.200390019

Reference yield: 75.0%

→ 3-methylnaphthalene-2-amine (10546-24-4)

Guidance literature:

Reference yield:

3-methyl-naphthalen-2-ol (17324-04-8) → 3-methylnaphthalene-2-amine (10546-24-4)

Guidance literature:

With ammonium sulfite; ammonia; water;

upstream raw materials:

3-methyl-naphthalen-2-ol

2-Methyl-3-nitronaphthalene

2-Amino-3-naphthoic acid

3-hydroxy-2-naphthoic acid methyl ester

Downstream raw materials:

2-Methylnaphthalene

3-Methylnaphthalin-2-carbonitril

N-(3-methyl-[2]naphthyl)-benzamide

2-Methyl-3-nitronaphthalene

Refernces

• 1、 Yusa, Yukinori,Kaito, Isao,Akiyama, Katsuhiro,Mikami, Koichi. "Asymmetric catalysis of homo-coupling of 3-substituted naphthylamine and hetero-coupling with 3-substituted naphthol leading to 3,3′-dimethyl-2, 2′-diaminobinaphthyl and -2-amino-2′-hydroxybinaphthyl". . p. 224 - 228. Retrieved 2010.
• 2、 -. "Phenyl substituted fused tricyclic compound and uses thereof". Paragraph 0182; 0184; 0185; 0186. . Retrieved 2019/05/16.
• 3、 Li, Gong-Qiang,Gao, Hongyin,Keene, Craig,Devonas, Michael,Ess, Daniel H.,Kürti, László. "Organocatalytic aryl-aryl bond formation: An atroposelective [3,3]-rearrangement approach to BINAM derivatives". supporting information. p. 7414 - 7417. Retrieved 2013/06/27.