(22S,25R)-5α-Solanidan-3β-ol

Base Information

• Chemical Name: (22S,25R)-5α-Solanidan-3β-ol
• CAS No.: 11004-30-1
• Molecular Formula: C₂₇H₄₅NO
• Molecular Weight: 399.66
• Mol file: 11004-30-1.mol

Synonyms:5a,22bH,25aH-Solanidan-3b-ol (7CI); Isosolanidan-3b-ol (6CI); 1H-Naphth[2',1':4,5]indeno[1,2-b]indolizine, solanidan-3-ol deriv.;(22S,25R)-5a-Solanidan-3b-ol; 22,25-Isodemissidine;Dihydro-22,25-isosolanidine; Isodemissidine

Chemical Property of (22S,25R)-5α-Solanidan-3β-ol

Chemical Property:

• Vapor Pressure: 8.57E-12mmHg at 25°C
• Refractive Index: 1.6840 (estimate)
• Boiling Point: 493.1°Cat760mmHg
• Flash Point: 212.4°C
• PSA: 23.47000
• Density: 1.08g/cm³
• LogP: 5.67280

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (22S,25R)-5α-Solanidan-3β-ol

There total 23 articles about (22S,25R)-5α-Solanidan-3β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C27H45NO2 (26442-75-1) → C27H45NO (474-08-8,3922-07-4,6785-43-9,11004-30-1,78513-80-1,104527-33-5,107382-01-4)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 12h; Ambient temperature;

Reference yield:

tetrahydrosolasodine-A (1449-16-7,1667-29-4,14374-02-8,16991-51-8,24694-74-4,36227-15-3,38623-69-7,53906-33-5,55902-91-5,62928-57-8,97100-57-7,98048-21-6,115792-26-2,115792-43-3) → C27H45NO (474-08-8,3922-07-4,6785-43-9,11004-30-1,78513-80-1,104527-33-5,107382-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: CrO₃ / acetic acid / Ambient temperature

2: NaBH₄ / ethanol / 12 h / Ambient temperature

With chromium(VI) oxide; sodium tetrahydroborate; In ethanol; acetic acid;

Reference yield:

(22S,25R)-22,26-Epimino-5α-cholestane-3β,16β-diol (14374-02-8) → 22(S),25(R)-demissidine (11004-30-1) + 5α,22β,25αH-solanidan-3-one (126639-38-1)

Guidance literature:

With chromium(VI) oxide; acetic acid; acetone; Reagens 4: Schwefelsaeure, Reagens 5: Wasser ; und Hyrierung des Reaktionsprodukts an Palladium/Kohle in Aethylacetat;

DOI:10.1021/jo01362a047

upstream raw materials:

(22S,25R)-22,26-Epimino-5α-cholestane-3β,16β-diol

5α,22β,25αH-solanidan-3-one

(22S,25R)-22,26-epiminocholest-5-ene-3β,16β-diol

(25R)-22,26-epiminocholesta-5,22(N)-diene-3β,16β-diol diacetate