L-Phenylalanine, 4-[[(3,5-dichloro-4-pyridinyl)carbonyl]amino]-N-[2-[(1-methyl-1H-imidaz ol-2-yl)thio]-3-oxospiro[3.5]non-1-en-1-yl]-, ethyl ester

Base Information

Chemical Name:L-Phenylalanine, 4-[[(3,5-dichloro-4-pyridinyl)carbonyl]amino]-N-[2-[(1-methyl-1H-imidaz ol-2-yl)thio]-3-oxospiro[3.5]non-1-en-1-yl]-, ethyl ester
CAS No.:571153-51-0
Molecular Formula:C30H31Cl2N5O4S
Molecular Weight:628.579
Hs Code.:

L-Phenylalanine,
4-[[(3,5-dichloro-4-pyridinyl)carbonyl]amino]-N-[2-[(1-methyl-1H-imidaz
ol-2-yl)thio]-3-oxospiro[3.5]non-1-en-1-yl]-, ethyl ester

Synonyms:

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Chemical Property of L-Phenylalanine, 4-[[(3,5-dichloro-4-pyridinyl)carbonyl]amino]-N-[2-[(1-methyl-1H-imidaz ol-2-yl)thio]-3-oxospiro[3.5]non-1-en-1-yl]-, ethyl ester

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Technology Process of L-Phenylalanine, 4-[[(3,5-dichloro-4-pyridinyl)carbonyl]amino]-N-[2-[(1-methyl-1H-imidaz ol-2-yl)thio]-3-oxospiro[3.5]non-1-en-1-yl]-, ethyl ester

There total 4 articles about L-Phenylalanine, 4-[[(3,5-dichloro-4-pyridinyl)carbonyl]amino]-N-[2-[(1-methyl-1H-imidaz ol-2-yl)thio]-3-oxospiro[3.5]non-1-en-1-yl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: C₄H₅ClN₂S

: 455262-36-9
ethyl (2S)-2-[(3-oxospiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propanoate

: 571153-51-0
3-{4-[(3,5-dichloro-pyridine-4-carbonyl)-amino]-phenyl}-2-[2-(1-methyl-1H-imidazol-2-ylsulfanyl)-3-oxo-spiro[3.5]non-1-en-1-ylamino]-propionic acid ethyl ester

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/ol034701n

Reference yield:

: 2719-27-9
cyclohexanylcarbonyl chloride

: 571153-51-0
3-{4-[(3,5-dichloro-pyridine-4-carbonyl)-amino]-phenyl}-2-[2-(1-methyl-1H-imidazol-2-ylsulfanyl)-3-oxo-spiro[3.5]non-1-en-1-ylamino]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / triethylamine / diethyl ether; hexane / 24 h / Heating

2: 92 percent / hydrochloric acid / H₂O / 24 h / 20 °C

3: 95 percent / tetrahydrofuran / 24 h / 20 °C

4: 89 percent / tetrahydrofuran / 12 h / 20 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; diethyl ether; hexane; water;
DOI:10.1021/ol034701n

Reference yield:

: 10576-21-3
3-ethoxyspiro[3.5]non-2-en-1-one

: 571153-51-0
3-{4-[(3,5-dichloro-pyridine-4-carbonyl)-amino]-phenyl}-2-[2-(1-methyl-1H-imidazol-2-ylsulfanyl)-3-oxo-spiro[3.5]non-1-en-1-ylamino]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / hydrochloric acid / H₂O / 24 h / 20 °C

2: 95 percent / tetrahydrofuran / 24 h / 20 °C

3: 89 percent / tetrahydrofuran / 12 h / 20 °C

With hydrogenchloride; In tetrahydrofuran; water;
DOI:10.1021/ol034701n