Cyclopent[b]indole-3-acetic acid, 5-bromo-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-1-oxo-, methyl ester, (3R)-

Base Information

• Chemical Name: Cyclopent[b]indole-3-acetic acid, 5-bromo-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-1-oxo-, methyl ester, (3R)-
• CAS No.: 571170-90-6
• Molecular Formula: C₂₁H₁₆BrClFNO₃
• Molecular Weight: 464.718
• Mol file: 571170-90-6.mol

Synonyms:

Chemical Property of Cyclopent[b]indole-3-acetic acid, 5-bromo-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-1-oxo-, methyl ester, (3R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopent[b]indole-3-acetic acid, 5-bromo-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-1-oxo-, methyl ester, (3R)-

There total 1 articles about Cyclopent[b]indole-3-acetic acid, 5-bromo-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-1-oxo-, methyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[5-bromo-4-(4-chloro-benzyl)-7-fluoro-1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl]-acetic acid methyl ester (571170-89-3) → [5-bromo-4-(4-chloro-benzyl)-7-fluoro-1-oxo-1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl]-acetic acid methyl ester (571170-90-6)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; water;

DOI:10.1016/j.bmcl.2006.10.055

Reference yield: 27.0%

[5-bromo-4-(4-chloro-benzyl)-7-fluoro-1-oxo-1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl]-acetic acid methyl ester (571170-90-6) + sodium methansulfinate (20277-69-4) → [4-(4-chloro-benzyl)-7-fluoro-5-methanesulfonyl-1-oxo-1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl]-acetic acid methyl ester (929039-04-3)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; copper(l) iodide;

DOI:10.1016/j.bmcl.2006.10.055

Reference yield:

[5-bromo-4-(4-chloro-benzyl)-7-fluoro-1-oxo-1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl]-acetic acid methyl ester (571170-90-6) → [4-(4-chloro-benzyl)-7-fluoro-5-methanesulfonyl-1-oxo-1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl]-acetic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 27 percent / CuI; NMP

2: 50 percent / aq. NaOH / tetrahydrofuran

With 1-methyl-pyrrolidin-2-one; sodium hydroxide; copper(l) iodide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2006.10.055

upstream raw materials:

[5-bromo-4-(4-chloro-benzyl)-7-fluoro-1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl]-acetic acid methyl ester

Downstream raw materials:

[4-(4-chloro-benzyl)-7-fluoro-5-methanesulfonyl-1-oxo-1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl]-acetic acid methyl ester