Benzoic acid 4-phenylphenacyl ester

Base Information

• Chemical Name: Benzoic acid 4-phenylphenacyl ester
• CAS No.: 4347-61-9
• Molecular Formula: C21H16O3
• Molecular Weight: 316.356
• Hs Code.: 2916310090
• Mol file: 4347-61-9.mol

Synonyms:Ethanone, 2-(benzoyloxy)-1-[1,1‘-biphenyl]-4-yl-;HMS1402P11;p-Phenylphenacyl benzoate;

Chemical Property of Benzoic acid 4-phenylphenacyl ester

Chemical Property:

• Vapor Pressure: 1.29E-10mmHg at 25°C
• Boiling Point: 512.5°C at 760 mmHg
• Flash Point: 226.6°C
• PSA: 43.37000
• Density: 1.178g/cm³
• LogP: 4.39330

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid 4-phenylphenacyl ester

There total 6 articles about Benzoic acid 4-phenylphenacyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Bromo-4'-phenylacetophenone (135-73-9) + benzoic acid (65-85-0,8013-63-6) → 2-(benzoyloxy)-1-[1,1'-biphenyl]-4-yl-ethanone (4347-61-9)

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1021/ac50064a047

Reference yield:

biphenyl (92-52-4,1594-86-1) → 2-(benzoyloxy)-1-[1,1'-biphenyl]-4-yl-ethanone (4347-61-9)

Guidance literature:

Multi-step reaction with 3 steps

1: AlCl₃; carbon disulfide

2: acetic acid; bromine / 45 - 50 °C

3: aqueous ethanol

With carbon disulfide; aluminium trichloride; ethanol; bromine; acetic acid;

DOI:10.1021/ja01372a045

Reference yield:

4-biphenyl-carboxylic acid chloride (14002-51-8) → 2-(benzoyloxy)-1-[1,1'-biphenyl]-4-yl-ethanone (4347-61-9)

Guidance literature:

Multi-step reaction with 2 steps

2: CuCl₂; dioxane

With 1,4-dioxane; copper dichloride;

DOI:10.1021/ja01155a086

upstream raw materials:

sodium benzoate

2-Bromo-4'-phenylacetophenone

2-diazo-1-biphenyl-4-yl-ethanone

benzoic acid

Refernces

• 1、 Miller, Jack M.,Brindle, Ian D.,Cater, Stephen R.,So, Kwok-Hung,Clark, James H.. "Potassium Fluoride Assisted Derivatization of Carboxylic Acids to Phenacyl Esters for Determination by High-Performance Liquid Chromatography". . p. 2430 - 2432. Retrieved 2007/10/02.