4-Phospho D-Erythronate

Base Information

• Chemical Name: 4-Phospho D-Erythronate
• CAS No.: 57229-25-1
• Molecular Formula: C4H9O8P
• Molecular Weight: 216.08300
• Mol file: 57229-25-1.mol

Synonyms:(2R,3R)-2,3-dihydroxy-4-phosphonooxybutanoic acid;

Chemical Property of 4-Phospho D-Erythronate

Chemical Property:

• PSA: 154.33000
• LogP: -2.09790
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Methanol (Slightly, Water (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

4-PhosphoD-Erythronate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Phospho-D-erythronate is an intermediate in the synthesis of pyridoxal 5'-phosphate in some bacteria and an inhibitor of ribose 5-phosphate isomerase. Phosphorylated aldonic acids are strong inhibitors of 6-phosphogluconate dehydrogenase, and 4-phospho-D-erythronate (4PE) and 4-phospho-D-erythronohydroxamate are two of the strongest inhibitors of the Trypanosoma brucei enzyme. 4-Phospho-D-erythronate is an intermediate in the synthesis of pyridoxal 5''-phosphate in some bacteria and an inhibitor of ribose 5-phosphate isomerase. Phosphorylated aldonic acids are strong inhibitors of 6-phosphogluconate dehydrogenase, and 4-phospho-D-erythronate (4PE) and 4-phospho-D-erythronohydroxamate are two of the strongest inhibitors of the Trypanosoma brucei enzyme.

Technology Process of 4-Phospho D-Erythronate

There total 4 articles about 4-Phospho D-Erythronate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C39H39O8P (1293913-18-4) → 4-phospho-D-erythronate (57229-25-1)

Guidance literature:

With 30% Pd/C; hydrogen; In methanol; water; at 4 ℃; for 12h; under 3102.97 Torr; Autoclave; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.02.045

Reference yield:

Glucosaccharinsaeure-6-phosphat (92986-77-1,92986-81-7) → 4-phospho-D-erythronate (57229-25-1)

Guidance literature:

With sodium hypobromide;

DOI:10.1021/jo01044a524

Reference yield:

D-erythrose 4-phosphate (585-18-2,80206-32-2) → 4-phospho-D-erythronate (57229-25-1)

Guidance literature:

With potassium permanganate; In perchloric acid; at 35 ℃; Rate constant; Thermodynamic data; ΔH(excit.), ΔS(excit.);

upstream raw materials:

Glucosaccharinsaeure-6-phosphat

Methyl-2,3-O-benzoyl-4-O-trityl-D-erythronat

D-erythrose 4-phosphate

C₃₉H₃₉O₈P