1,3-Bis(methoxymethoxy)benzene

Base Information

• Chemical Name: 1,3-Bis(methoxymethoxy)benzene
• CAS No.: 57234-29-4
• Molecular Formula: C10H14O4
• Molecular Weight: 198.219
• DSSTox Substance ID: DTXSID901306842
• Nikkaji Number: J1.547.028C
• Mol file: 57234-29-4.mol

Synonyms:1,3-Bis(methoxymethoxy)benzene;57234-29-4;1,3-di(methoxymethoxy)benzene;Benzene, 1,3-bis(methoxymethoxy)-;SCHEMBL1607526;TZZPMRGYEPMHLA-UHFFFAOYSA-N;DTXSID901306842;Resorcinol Bis(methoxymethyl) Ether;MFCD27925713;1,3-bis{[(methyloxy)methyl]oxy}benzene;B5643;CS-0453812;FT-0712579;T71077

Chemical Property of 1,3-Bis(methoxymethoxy)benzene

Chemical Property:

• Refractive Index: 1.4990 to 1.5030
• Boiling Point: 137°C/7mmHg(lit.)
• PSA: 36.92000
• Density: 1.1262 g/cm3
• LogP: 1.65200
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 198.08920892
• Heavy Atom Count: 14
• Complexity: 126

Purity/Quality:

99% ^*data from raw suppliers

1,3-Bis(methoxymethoxy)benzene >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCOC1=CC(=CC=C1)OCOC

Technology Process of 1,3-Bis(methoxymethoxy)benzene

There total 8 articles about 1,3-Bis(methoxymethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

chloromethyl methyl ether (107-30-2) + recorcinol (108-46-3) → 1,3-bis(methoxymethyl)resorcinol (57234-29-4)

Guidance literature:

recorcinol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

chloromethyl methyl ether; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 27h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.9b00995

Reference yield: 97.0%

ethyl chloromethyl ether (3188-13-4) + recorcinol (108-46-3) → 1,3-bis(methoxymethyl)resorcinol (57234-29-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;

DOI:10.1021/jo801312r

Reference yield: 77.0%

bromethyl methyl ether (13057-17-5) + recorcinol (108-46-3) → 1,3-bis(methoxymethyl)resorcinol (57234-29-4)

Guidance literature:

recorcinol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.166667h;

bromethyl methyl ether; In tetrahydrofuran; mineral oil; at 0 - 23 ℃; for 1.5h;

DOI:10.1021/jacs.7b01089

upstream raw materials:

chloromethyl methyl ether

recorcinol

methoxymethoxy chloride

ethyl chloromethyl ether

Downstream raw materials:

2-((3R)-1-hydroxy-3,7-dimethyloct-7-enyl)bis(O-methoxymethyl)resorcinol

2,,6-bis-(methoxymethoxy)benzaldehyde

2-(1-hydroxy-3-methoxymethoxy-7-methyl-6-octenyl)-1,3-bis(O-methoxymethyl)resorcinol

2-iodo-3-(methoxymethoxy)phenol