Glycine-d5

Base Information

• Chemical Name: Glycine-d5
• CAS No.: 4896-77-9
• Molecular Formula: C2D5NO2
• Molecular Weight: 80.0275
• European Community (EC) Number: 225-518-6
• Nikkaji Number: J262.518K
• Mol file: 4896-77-9.mol

Synonyms:Glycine-d5;4896-77-9;(2H5)Glycine;Aminoacetic Acid-d5;perdeuterioglycine;Deuterated glycine;deuterio 2,2-dideuterio-2-(dideuterioamino)acetate;EINECS 225-518-6;Glycine-N,N,1,2,2-d5;perdeuteroglycine;pentadeuteroglycine;Glycine D5;pentadeuterioglycine;((2)H5)glycine;C2D5NO2;Glycine-d5, 98 atom % D;CHEBI:132194;C2-D5-N-O2;HY-Y0966S8;AKOS030242541;CS-T-55422;MS-22719;2-[(?H?)amino](?H?)ethan(?H)oic acid;CS-0376465

Chemical Property of Glycine-d5

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 0.00359mmHg at 25°C
• Melting Point: 240 °C (dec.)(lit.)
• Refractive Index: 1.469
• Boiling Point: 240.9 °C at 760 mmHg
• Flash Point: 99.5 °C
• PSA: 63.32000
• Density: 1.338 g/cm³
• LogP: -0.27000
• Storage Temp.: Refrigerator
• Solubility.: Methanol (Slightly), Water (Sparingly)
• XLogP3: -3.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 80.063412132
• Heavy Atom Count: 5
• Complexity: 42.9

Purity/Quality:

98%min ^*data from raw suppliers

Glycine-d5 ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(C(=O)O)N
• Isomeric SMILES: [2H]C([2H])(C(=O)O[2H])N([2H])[2H]
• Uses: Deuterated Glycine (G615990) Deuterated Glycine (G615990). Non-essential amino acid for human development. An inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Technology Process of Glycine-d5

There total 2 articles about Glycine-d5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N,O-d3-glycine (4896-76-8) → glycine-d5 (4896-77-9)

Guidance literature:

With deuterium; platinum(IV) oxide; at 150 ℃; for 72h;

DOI:10.1016/0022-2364(84)90100-8

Reference yield:

→ glycine-d5 (4896-77-9)

Guidance literature:

C.C-Dideutero-glycin in Deuteriumoxyd, wiederholtes Eindampfen i. V. ueber P2O5;

DOI:10.1021/ja01071a008

Reference yield:

glycine-d5 (4896-77-9) → paraformaldehyde-d2 (1664-98-8,43094-80-0) + carbon dioxide (124-38-9,18923-20-1)

Guidance literature:

With water; pyridinium hydrobromide perbromide; acetic acid; at 44.9 ℃; absence of kinetic isotope effect;

upstream raw materials:

N,N,O-d3-glycine

Downstream raw materials:

(-)-lankacidin C

Sedecamycin

Acetic acid (3E,5E,9E,11E)-(1S,2R,7S,13S,15R,19R)-7-acetoxy-1,4,10,19-tetramethyl-17,18-dioxo-2-(2-oxo-propionylamino)-16-oxa-bicyclo[13.2.2]nonadeca-3,5,9,11-tetraen-13-yl ester

paraformaldehyde-d2

Refernces

• 1、 Blomquist et al.. "". . p. 338. Retrieved 1966.