N-(4-METHYLQUINAZOLIN-2-YL)GUANIDINE

Base Information

• Chemical Name: N-(4-METHYLQUINAZOLIN-2-YL)GUANIDINE
• CAS No.: 716-11-0
• Molecular Formula: C10H11N5
• Molecular Weight: 201.23
• Hs Code.: 2933990090
• Mol file: 716-11-0.mol

Synonyms:GNF-Pf-3515;4-methyl-2-quinazolylguanidine;N-(4-methyl-2-quinazolinyl)guanidine;4-methylquinazolin-2-ylguanidine;amino(4-methylquinazolin-2-yl)carboxamidine;(4-Methyl-chinazolin-2-yl)-guanidin;N-(4-methylquinazolin-2-yl)guanidine;

Chemical Property of N-(4-METHYLQUINAZOLIN-2-YL)GUANIDINE

Chemical Property:

• Vapor Pressure: 6.43E-09mmHg at 25°C
• Boiling Point: 467.6°C at 760 mmHg
• Flash Point: 236.6°C
• PSA: 87.68000
• Density: 1.4g/cm³
• LogP: 2.11660

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Methylquinazolin-2-yl)guanidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-METHYLQUINAZOLIN-2-YL)GUANIDINE

There total 5 articles about N-(4-METHYLQUINAZOLIN-2-YL)GUANIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

dicyandiamide (127099-85-8,780722-26-1) + 2,2,4-trimethyl-1,2-dihydroquinoline (147-47-7,26780-96-1,389806-19-3) → NSC 403387 (716-11-0)

Guidance literature:

With hydrogenchloride; at 105 ℃; for 0.5h;

DOI:10.1021/jacs.9b11232

Reference yield: 51.0%

→ NSC 403387 (716-11-0)

Guidance literature:

With hydrogenchloride; at 105 ℃;

Reference yield: 34.0%

trimethylaluminum chloride + (4-methyl-quinazolin-2-yl)-carbamonitrile (54789-74-1) → NSC 403387 (716-11-0)

Guidance literature:

With ammonium chloride; ammonia; In chloroform; toluene;

upstream raw materials:

2-aminoacetophenone hydrochloride

N-Cyanoguanidine

(4-methyl-quinazolin-2-yl)-carbamonitrile

dicyandiamide

Downstream raw materials:

2-((4-methylquinazolin-2-yl)amino)quinazolin-4(1H)-one

Refernces

• 1、 ?hlund, Daniel,Akhunzianov, Almaz,Br?nnstr?m, Kristoffer,Chand, Karam,Chorell, Erik,Deiana, Marco,Doimo, Mara,Hedenstr?m, Mattias,Jamroskovic, Jan,Kasho, Kazutoshi,Kumar, Rajendra,Mason, James E.,Medini, Paolo,Nath Das, Rabindra,Obi, Ikenna,Pourbozorgi, Parham L.,Sabouri, Nasim,Sulis Sato, Sebastian,Wanrooij, Sjoerd. "Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization". supporting information. . Retrieved 2020/02/13.
• 2、 -. "Guanidines which are agonist/antagonist ligands for neuropeptide FF (NPFF) receptors". . . Retrieved 2008/06/13.