Technology Process of 2'-deoxy-3-methylpseudouridine
There total 6 articles about 2'-deoxy-3-methylpseudouridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 54 percent / pyridine / 6 h / Ambient temperature
2: 91 percent / dimethylformamide / 12 h / Ambient temperature
3: 1.) ammonium sulfate, 2.) 2,2'-azobis(2-methylpropionitrile), tri-butyltin hydride / 1.) hexamethyldisilazane, reflux, 2.) toluene, reflux, 2 h.
4: 65 percent / M tetra-butylammonium fluoride / tetrahydrofuran
With
ammonium sulfate; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride;
In
tetrahydrofuran; pyridine; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(00)81043-5
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 91 percent / dimethylformamide / 12 h / Ambient temperature
2: 1.) ammonium sulfate, 2.) 2,2'-azobis(2-methylpropionitrile), tri-butyltin hydride / 1.) hexamethyldisilazane, reflux, 2.) toluene, reflux, 2 h.
3: 65 percent / M tetra-butylammonium fluoride / tetrahydrofuran
With
ammonium sulfate; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(00)81043-5
