tert-butyl 3,5-diamino-1H-indazole-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3,5-diamino-1H-indazole-1-carboxylate
• CAS No.: 574729-26-3
• Molecular Formula: C12H16N4O2
• Molecular Weight: 248.285
• Mol file: 574729-26-3.mol

Synonyms:tert-butyl 3,5-diaminoindazole-1-carboxylate;3,5-diaminoindazol-1-carboxylic acid-tert-butyl ester;tert-butyl 3,5-diamino-1H-indazole-1-carboxylate;

Chemical Property of tert-butyl 3,5-diamino-1H-indazole-1-carboxylate

Chemical Property:

• Boiling Point: 464.0±48.0 °C(Predicted)
• PKA: 3.89±0.10(Predicted)
• PSA: 96.16000
• Density: 1.34±0.1 g/cm3(Predicted)
• LogP: 3.14630

Purity/Quality:

98% ^*data from raw suppliers

3,5-Diamino-indazole-1-carboxylicacidtert-butylester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 3,5-diamino-1H-indazole-1-carboxylate

There total 4 articles about tert-butyl 3,5-diamino-1H-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

tert-butyl 3-amino-5-nitro-1H-indazole-1-carboxylate (574729-25-2) → tert-butyl 3,5-diamino-1H-indazole-1-carboxylate (574729-26-3)

Guidance literature:

With 10% palladium on activated charcoal; hydrogen; In methanol;

DOI:10.1016/j.bmcl.2010.10.069

Reference yield:

5-nitro-1H-indazol-3-amine (41339-17-7) → tert-butyl 3,5-diamino-1H-indazole-1-carboxylate (574729-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 22 °C

With dmap; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1021/acsmedchemlett.7b00344

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 3,5-diamino-1H-indazole-1-carboxylate (574729-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 22 °C

With dmap; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1021/acsmedchemlett.7b00344

upstream raw materials:

tert-butyl 3-amino-5-nitro-1H-indazole-1-carboxylate

5-nitro-1H-indazol-3-amine

di-tert-butyl dicarbonate

2-fluoro-5-nitrobenzonitrile

Downstream raw materials:

3-amino-5-[2-(3-hydroxy-phenyl)-acetylamino]-indazol-1-carboxylic acid-tert-butyl ester

3-amino-5-[(1-{2-oxo-2-[4-(4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]ethyl}-pyrrolidine-3-carbonyl)-amino]-indazole-1-carboxylic acid tert-butyl ester

3-Amino-5-[4-tert-butoxycarbonylamino-2-(3,4-dichloro-phenyl)-butyrylamino]-indazole-1-carboxylic acid tert-butyl ester

tert-butyl-3-amino-5-[3-(3-methoxybenzyl)ureido]indazole-1-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 574729-26-3 tert-butyl 3,5-diamino-1H-indazole-1-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send