Propanoic acid, 3-[[7-[3-[2-(2-chlorophenyl)ethyl]-4-hydroxyphenoxy]-2,3-dihydro-6-meth yl-1H-inden-4-yl]amino]-3-oxo-

Base Information

Chemical Name:Propanoic acid, 3-[[7-[3-[2-(2-chlorophenyl)ethyl]-4-hydroxyphenoxy]-2,3-dihydro-6-meth yl-1H-inden-4-yl]amino]-3-oxo-
CAS No.:575504-14-2
Molecular Formula:C27H26ClNO5
Molecular Weight:479.96
Hs Code.:

Synonyms:

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Chemical Property of Propanoic acid, 3-[[7-[3-[2-(2-chlorophenyl)ethyl]-4-hydroxyphenoxy]-2,3-dihydro-6-meth yl-1H-inden-4-yl]amino]-3-oxo-

Chemical Property:

Purity/Quality:

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Technology Process of Propanoic acid, 3-[[7-[3-[2-(2-chlorophenyl)ethyl]-4-hydroxyphenoxy]-2,3-dihydro-6-meth yl-1H-inden-4-yl]amino]-3-oxo-

There total 5 articles about Propanoic acid, 3-[[7-[3-[2-(2-chlorophenyl)ethyl]-4-hydroxyphenoxy]-2,3-dihydro-6-meth yl-1H-inden-4-yl]amino]-3-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₀ClNO₅

: 575504-14-2
N-(7-{3-[2-(2-chlorophenyl)ethyl]-4-hydroxyphenoxy}-6-methylindan-4-yl)malonamic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 60 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.12.002

Reference yield:

: bis(4-methoxyphenyl)iodonium tetrafluoroborate

: 575504-14-2
N-(7-{3-[2-(2-chlorophenyl)ethyl]-4-hydroxyphenoxy}-6-methylindan-4-yl)malonamic acid

Guidance literature:: Multi-step reaction with 7 steps

1: copper; triethylamine / dichloromethane / 120 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

3: pyridine / dichloromethane / 3 h / 20 °C

4: trifluoromethylsulfonic anhydride / dichloromethane / 15 h / 20 °C

5: triethylsilane; trifluoroacetic acid / dichloromethane / 20 °C

6: boron tribromide / dichloromethane / -78 - 20 °C

7: water; sodium hydroxide / methanol / 0.5 h / 60 °C / Inert atmosphere

With pyridine; triethylsilane; trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; water; hydrogen; boron tribromide; copper; triethylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; ethyl acetate; 4: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmc.2012.12.002

Reference yield:

: 575505-40-7
ethyl N-[7-(4-methoxyphenoxy)-6-methylindan-4-yl]malonamate

: 575504-14-2
N-(7-{3-[2-(2-chlorophenyl)ethyl]-4-hydroxyphenoxy}-6-methylindan-4-yl)malonamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoromethylsulfonic anhydride / dichloromethane / 15 h / 20 °C

2: triethylsilane; trifluoroacetic acid / dichloromethane / 20 °C

3: boron tribromide / dichloromethane / -78 - 20 °C

4: water; sodium hydroxide / methanol / 0.5 h / 60 °C / Inert atmosphere

With triethylsilane; trifluoromethylsulfonic anhydride; water; boron tribromide; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; 1: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmc.2012.12.002