Technology Process of 1H-Indene-4-carbonitrile,
2,3-dihydro-6-methyl-7-[3-(1-methylethyl)-4-(phenylmethoxy)phenoxy]-
There total 8 articles about 1H-Indene-4-carbonitrile,
2,3-dihydro-6-methyl-7-[3-(1-methylethyl)-4-(phenylmethoxy)phenoxy]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(4-Benzyloxy-3-isopropylphenoxy)-7-iodo-5-methylindane;
With
1-methyl-pyrrolidin-2-one; potassium cyanide;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0);
In
argon;
at 80 ℃;
for 12h;
water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetonitrile / 29 h / Reflux
2.1: iodine tris(trifluoroacetate); acetic anhydride; trifluoroacetic acid / 16 h / 4 °C
2.2: 0.5 h
3.1: bronze powder; triethylamine / dichloromethane / 120 h / 20 °C
4.1: platinum(IV) oxide; hydrogen / ethyl acetate / 2 h / 20 °C
5.1: hydrogenchloride / water; toluene / Heating
5.2: 0.08 h / Cooling with ice
5.3: 0.33 h / 20 - 100 °C
6.1: 1,1'-bis-(diphenylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) / 1-methyl-pyrrolidin-2-one / 80 °C / Inert atmosphere
With
hydrogenchloride; platinum(IV) oxide; 1,1'-bis-(diphenylphosphino)ferrocene; bronze powder; iodine tris(trifluoroacetate); hydrogen; acetic anhydride; potassium carbonate; triethylamine; trifluoroacetic acid; bis(dibenzylideneacetone)-palladium(0);
In
1-methyl-pyrrolidin-2-one; dichloromethane; water; ethyl acetate; toluene; acetonitrile;
DOI:10.1016/j.bmc.2012.03.056
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: nitric acid; acetic acid / water / 0 - 20 °C
2.1: bronze powder; triethylamine / dichloromethane / 120 h / 20 °C
3.1: platinum(IV) oxide; hydrogen / ethyl acetate / 2 h / 20 °C
4.1: hydrogenchloride / water; toluene / Heating
4.2: 0.08 h / Cooling with ice
4.3: 0.33 h / 20 - 100 °C
5.1: 1,1'-bis-(diphenylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) / 1-methyl-pyrrolidin-2-one / 80 °C / Inert atmosphere
With
hydrogenchloride; platinum(IV) oxide; 1,1'-bis-(diphenylphosphino)ferrocene; bronze powder; hydrogen; nitric acid; acetic acid; triethylamine; bis(dibenzylideneacetone)-palladium(0);
In
1-methyl-pyrrolidin-2-one; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1016/j.bmc.2012.03.056
