4-Bromo-6,8-difluoroquinoline

Base Information

Chemical Name:4-Bromo-6,8-difluoroquinoline
CAS No.:577692-34-3
Molecular Formula:C9H4BrF2N
Molecular Weight:244.038
Hs Code.:
DSSTox Substance ID:DTXSID80582995
Wikidata:Q82474507
Mol file:577692-34-3.mol

Synonyms:4-bromo-6,8-difluoroquinoline;577692-34-3;4-bromo-6,8-difluoro-quinoline;SCHEMBL3254363;DTXSID80582995;VDMKLKJLEPUQJH-UHFFFAOYSA-N;MFCD12674969;SB72027

Suppliers and Price of 4-Bromo-6,8-difluoroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-Bromo-6,8-difluoroquinoline 97%
1g
$ 703.00

Chemenu
4-Bromo-6,8-difluoroquinoline 97%
1g
$ 664.00

American Custom Chemicals Corporation
4-BROMO-6,8-DIFLUOROQUINOLINE 95.00%
5MG
$ 505.55

Total 2 raw suppliers

Chemical Property of 4-Bromo-6,8-difluoroquinoline

Chemical Property:

Vapor Pressure:0.003mmHg at 25°C
Boiling Point:296.048oC at 760 mmHg
Flash Point:132.846oC
PSA：12.89000
Density:1.726g/cm3
LogP:3.27550
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:242.94952
Heavy Atom Count:13
Complexity:191

Purity/Quality:

95% ^*data from raw suppliers

4-Bromo-6,8-difluoroquinoline 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN=C2C(=CC(=CC2=C1Br)F)F

Technology Process of 4-Bromo-6,8-difluoroquinoline

There total 2 articles about 4-Bromo-6,8-difluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 243448-16-0
4-hydroxy-6,8-difluoro-quinoline

: 577692-34-3
4-bromo-6,8-difluoroquinoline

Guidance literature:: With phosphorus tribromide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1021/jo062168u

Reference yield:

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 577692-34-3
4-bromo-6,8-difluoroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: HC(OEt)3 / 145 °C

1.2: 50 - 145 °C

1.3: diphenyl ether / 250 °C

2.1: 59 percent / PBr₃ / dimethylformamide / 0.5 h / 20 °C

With phosphorus tribromide; orthoformic acid triethyl ester; In N,N-dimethyl-formamide;
DOI:10.1021/jo062168u

Reference yield:

: 577692-34-3
4-bromo-6,8-difluoroquinoline

: ((1S,2S,4S)/(1R,2R,4R)-4-carbamoyl-2-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester

: [(1S,3S,4S)/(1R,3R,4R)-4-(6,8-difluoro-quinolin-4-ylcarbamoyl)-2-hydroxy-cyclohexyl]-carbamic acid tert butyl ester

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 95 ℃; for 12h;