2-Hydroxy-5-(4-trifluoromethylphenyl)nicotinic acid

Base Information

• Chemical Name: 2-Hydroxy-5-(4-trifluoromethylphenyl)nicotinic acid
• CAS No.: 577967-76-1
• Molecular Formula: C13H8F3NO3
• Molecular Weight: 283.207
• DSSTox Substance ID: DTXSID60586355
• Wikidata: Q82478467

Synonyms:577967-76-1;2-HYDROXY-5-(4-TRIFLUOROMETHYLPHENYL)NICOTINIC ACID;2-Hydroxy-5-(4-(trifluoromethyl)phenyl)nicotinic acid;SCHEMBL3975183;SCHEMBL11161159;DTXSID60586355;PFRXFCDETPFONF-UHFFFAOYSA-N;MFCD18318044;AKOS005064460;2-Hydroxy-5-(4-trifluoromethylphenyl)nicotinic acid, 95%;2-oxo-5-[4-(trifluoromethyl)phenyl]-1H-pyridine-3-carboxylic acid;2-Oxo-5-[4-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxylic acid

Chemical Property of 2-Hydroxy-5-(4-trifluoromethylphenyl)nicotinic acid

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 283.04562760
• Heavy Atom Count: 20
• Complexity: 486

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CNC(=O)C(=C2)C(=O)O)C(F)(F)F

Technology Process of 2-Hydroxy-5-(4-trifluoromethylphenyl)nicotinic acid

There total 1 articles about 2-Hydroxy-5-(4-trifluoromethylphenyl)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-hydroxy-5-(4-trifluoromethyl-phenyl)-nicotinonitrile (577967-75-0) → 2-hydroxy-5-(4-trifluoromethyl-phenyl)-nicotinic acid (577967-76-1)

Guidance literature:

With hydrogenchloride; In acetic acid; for 18h; Heating / reflux;

Reference yield: 86.0%

quinoline (91-22-5) + 2-hydroxy-5-(4-trifluoromethyl-phenyl)-nicotinic acid (577967-76-1) → 2-hydroxy-5-(4-trifluoromethyl-phenyl)-pyridine

Guidance literature:

at 215 ℃; for 12h;

upstream raw materials:

2-hydroxy-5-(4-trifluoromethyl-phenyl)-nicotinonitrile

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