5H-Pyrrolo[3,2-d]pyrimidine, 7-[(2R,4R,5R)-3,3-difluoro-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl ]-1-(phenylmethyl)-2-pyrrolidinyl]-4-methoxy-

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Chemical Name:5H-Pyrrolo[3,2-d]pyrimidine, 7-[(2R,4R,5R)-3,3-difluoro-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl ]-1-(phenylmethyl)-2-pyrrolidinyl]-4-methoxy-
CAS No.:577978-40-6
Molecular Formula:C33H32F2N4O3
Molecular Weight:570.639
Hs Code.:

5H-Pyrrolo[3,2-d]pyrimidine,
7-[(2R,4R,5R)-3,3-difluoro-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl
]-1-(phenylmethyl)-2-pyrrolidinyl]-4-methoxy-

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Chemical Property of 5H-Pyrrolo[3,2-d]pyrimidine, 7-[(2R,4R,5R)-3,3-difluoro-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl ]-1-(phenylmethyl)-2-pyrrolidinyl]-4-methoxy-

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Technology Process of 5H-Pyrrolo[3,2-d]pyrimidine, 7-[(2R,4R,5R)-3,3-difluoro-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl ]-1-(phenylmethyl)-2-pyrrolidinyl]-4-methoxy-

There total 5 articles about 5H-Pyrrolo[3,2-d]pyrimidine, 7-[(2R,4R,5R)-3,3-difluoro-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl ]-1-(phenylmethyl)-2-pyrrolidinyl]-4-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 577978-37-1
ethyl 4-amino-4-N,N-dibenzyl-5-O-tert-butyldimethylsilyl-2,4-dideoxy-2,2-difluoro-D-erythro-pentanoate

: 577978-40-6
7-(1-benzyl-4-benzyloxy-5-benzyloxymethyl-3,3-difluoro-pyrrolidin-2-yl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / 10 percent Pd/C / ethanol / 1 h

2.1: 25 percent aq. TFA / 3 h

3.1: 0.50 g / NaH / tetrahydrofuran; dimethylformamide / 16 h / 20 °C

4.1: anisole; BuLi / diethyl ether / 0.17 h / -70 °C

4.2: diethyl ether / 0.5 h / -40 °C

5.1: 0.81 g / AcOH; sodium cyanoborohydride / methanol / 1 h

With n-butyllithium; hydrogen; sodium hydride; sodium cyanoborohydride; acetic acid; methoxybenzene; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030145r

Reference yield:

: (3R,4R)-4-Amino-2,2-difluoro-3,5-dihydroxy-pentanoic acid ethyl ester

: 577978-40-6
7-(1-benzyl-4-benzyloxy-5-benzyloxymethyl-3,3-difluoro-pyrrolidin-2-yl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 0.50 g / NaH / tetrahydrofuran; dimethylformamide / 16 h / 20 °C

2.1: anisole; BuLi / diethyl ether / 0.17 h / -70 °C

2.2: diethyl ether / 0.5 h / -40 °C

3.1: 0.81 g / AcOH; sodium cyanoborohydride / methanol / 1 h

With n-butyllithium; sodium hydride; sodium cyanoborohydride; acetic acid; methoxybenzene; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm030145r

Reference yield:

: (3R,4R)-4-Amino-5-(tert-butyl-dimethyl-silanyloxy)-2,2-difluoro-3-hydroxy-pentanoic acid ethyl ester

: 577978-40-6
7-(1-benzyl-4-benzyloxy-5-benzyloxymethyl-3,3-difluoro-pyrrolidin-2-yl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 25 percent aq. TFA / 3 h

2.1: 0.50 g / NaH / tetrahydrofuran; dimethylformamide / 16 h / 20 °C

3.1: anisole; BuLi / diethyl ether / 0.17 h / -70 °C

3.2: diethyl ether / 0.5 h / -40 °C

4.1: 0.81 g / AcOH; sodium cyanoborohydride / methanol / 1 h

With n-butyllithium; sodium hydride; sodium cyanoborohydride; acetic acid; methoxybenzene; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm030145r