3-METHYL-4-PYRIDINECARBOXYLIC ACID, HYDROCHLORIDE

Base Information

• Chemical Name: 3-METHYL-4-PYRIDINECARBOXYLIC ACID, HYDROCHLORIDE
• CAS No.: 577993-80-7
• Molecular Formula: C7H7NO2.ClH
• Molecular Weight: 173.59700
• Hs Code.: 2933399090
• Mol file: 577993-80-7.mol

Synonyms:

Chemical Property of 3-METHYL-4-PYRIDINECARBOXYLIC ACID, HYDROCHLORIDE

Chemical Property:

• PSA: 50.19000
• LogP: 1.89020
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

95% ^*data from raw suppliers

3-Methylisonicotinicacidhydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHYL-4-PYRIDINECARBOXYLIC ACID, HYDROCHLORIDE

There total 3 articles about 3-METHYL-4-PYRIDINECARBOXYLIC ACID, HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyl-isonicotinic acid (4021-12-9) → 3-methylpyridine-4-carboxylic acid hydrochloride (577993-80-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

Reference yield:

Methyl 3-methylpyridine-4-carboxylate (116985-92-3) → 3-methylpyridine-4-carboxylic acid hydrochloride (577993-80-7)

Guidance literature:

Methyl 3-methylpyridine-4-carboxylate; With water; lithium hydroxide; In methanol; at 20 ℃; for 15h;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

Reference yield:

3,4-Lutidin (583-58-4) → 4-methylpyridine-3-carboxylic acid hydrochloride (94015-05-1) + 3-methylpyridine-4-carboxylic acid hydrochloride (577993-80-7)

Guidance literature:

With hydrogenchloride; potassium permanganate; Multistep reaction; 1.) water, 5 d, room temperature;

upstream raw materials:

3,4-Lutidin

3-methyl-isonicotinic acid

Methyl 3-methylpyridine-4-carboxylate

Downstream raw materials:

1-[(tert-butoxy)carbonyl]-3-methylpiperidine-4-carboxylic acid

(3R,4R)-1-(tert-butoxycarbonyl)-3-methylpiperidine-4-carboxylic acid

(3S,4S)-1-(tert-butoxycarbonyl)-3-methylpiperidine-4-carboxylic acid

Refernces

• 1、 -. "COMPOUNDS USEFUL FOR ALTERING THE LEVELS OF BILE ACIDS FOR THE TREATMENT OF DIABETES AND CARDIOMETABOLIC DISEASE". Page/Page column 64. . Retrieved 2018/03/09.