Fluorescein 5-maleimide

Base Information

Chemical Name:Fluorescein 5-maleimide
CAS No.:75350-46-8
Molecular Formula:C24H13NO7
Molecular Weight:427.37
Hs Code.:29251900
DSSTox Substance ID:DTXSID80226327
Nikkaji Number:J733.674H
Wikidata:Q72478874
ChEMBL ID:CHEMBL4277594
Mol file:75350-46-8.mol

Synonyms:fluorescein 5-maleimide;fluorescein maleimide;fluorescein-maleimide

Suppliers and Price of Fluorescein 5-maleimide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Fluorescein 5-Maleimide
25mg
$ 496.00

Usbiological
Fluorescein 5-maleimide
1mg
$ 495.00

TRC
Fluorescein5-Maleimide(90%)
2.5mg
$ 50.00

TCI Chemical
Fluorescein-5-maleimide >97.0%(HPLC)
25mg
$ 197.00

Sigma-Aldrich
N-(5-Fluoresceinyl)maleimide ≥90% (HPLC), suitable for fluorescence, BioReagent
25mg
$ 270.00

Medical Isotopes, Inc.
Fluorescein5-Maleimide
125 mg
$ 1880.00

DC Chemicals
Fluorescein-5-maleimide >98%
1 g
$ 600.00

DC Chemicals
Fluorescein-5-maleimide >98%
250 mg
$ 300.00

Crysdot
Fluorescein-5-maleimide 95+%
25mg
$ 170.00

Crysdot
Fluorescein-5-maleimide 95+%
10mg
$ 100.00

Total 27 raw suppliers

Chemical Property of Fluorescein 5-maleimide

Chemical Property:

Melting Point:>275°C (dec.)
Boiling Point:769.1 °C at 760 mmHg
PKA:9.31±0.20(Predicted)
Flash Point:418.9 °C
PSA：113.37000
Density:1.73 g/cm³
LogP:3.16020
Storage Temp.:Amber Vial, -20°C Freezer, Under Inert Atmosphere
Solubility.:Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:427.06920175
Heavy Atom Count:32
Complexity:826

Purity/Quality:

97% ^*data from raw suppliers

Fluorescein 5-Maleimide ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC2=C(C=C1N3C(=O)C=CC3=O)C(=O)OC24C5=C(C=C(C=C5)O)OC6=C4C=CC(=C6)O
Uses Fluorescein-5-maleimide is the most widely used green fluorescent thiol-reactive dye. The reaction requires very mild condition and is highly specific.

Technology Process of Fluorescein 5-maleimide

There total 2 articles about Fluorescein 5-maleimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: N-(5-fluoresceinyl)maleamic acid

: 75350-46-8
N-(5-fluoresceinyl)maleimide

Guidance literature:: With 1,1,1,3,3,3-hexamethyl-disilazane; zinc(II) chloride; In N,N-dimethyl-formamide; benzene; for 2.5h; Heating;
DOI:10.1055/s-1998-2097

Reference yield:

: 3326-34-9
fluoresceinamine

: 75350-46-8
N-(5-fluoresceinyl)maleimide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / AcOH / 4 h

2: 87 percent / ZnCl₂, HMDS / benzene; dimethylformamide / 2.5 h / Heating

With acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; zinc(II) chloride; In N,N-dimethyl-formamide; benzene;
DOI:10.1055/s-1998-2097