Methyl 2-(pyridin-4-yl)-1,3-benzoxazole-7-carboxylate

Base Information

• Chemical Name: Methyl 2-(pyridin-4-yl)-1,3-benzoxazole-7-carboxylate
• CAS No.: 579525-07-8
• Molecular Formula: C14H10N2O3
• Molecular Weight: 254.24100
• Hs Code.: 2934999090
• Mol file: 579525-07-8.mol

Synonyms:methyl 2-pyridin-4-yl-1,3-benzoxazole-7-carboxylate;

Chemical Property of Methyl 2-(pyridin-4-yl)-1,3-benzoxazole-7-carboxylate

Chemical Property:

• PSA: 65.22000
• LogP: 2.67640
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Methyl2-(pyridin-4-yl)benzo[d]oxazole-7-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-(pyridin-4-yl)-1,3-benzoxazole-7-carboxylate

There total 2 articles about Methyl 2-(pyridin-4-yl)-1,3-benzoxazole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-hydroxy-3-isonicotinoylaminobenzoic acid methyl ester (579525-06-7) → [2-(4-pyridyl)benzoxazol-7-yl]carboxylic acid methyl ester (579525-07-8)

Guidance literature:

2-hydroxy-3-isonicotinoylaminobenzoic acid methyl ester; With toluene-4-sulfonic acid; In xylene; for 14h; Heating / reflux;

With toluene-4-sulfonic acid; for 2h; Heating / reflux;

Reference yield:

isonicotinoyl chloride hydrochloride (39178-35-3) → [2-(4-pyridyl)benzoxazol-7-yl]carboxylic acid methyl ester (579525-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran; N,N-dimethyl-aniline / 2 h / Cooling with ice

2: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 16 h / Reflux

With toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-aniline;

upstream raw materials:

2-hydroxy-3-isonicotinoylaminobenzoic acid methyl ester

isonicotinoyl chloride hydrochloride

Refernces

• 1、 -. "BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)". Page/Page column 65. . Retrieved 2009/08/16.