2,7-Dichloro-4-phenyl-1,8-naphthyridine

Base Information

Chemical Name:2,7-Dichloro-4-phenyl-1,8-naphthyridine
CAS No.:58035-57-7
Molecular Formula:C14H8Cl2N2
Molecular Weight:275.137
Hs Code.:
DSSTox Substance ID:DTXSID001278937
Nikkaji Number:J3.400.868J

Synonyms:2,7-dichloro-4-phenyl-1,8-naphthyridine;SCHEMBL18455611;DTXSID001278937;58035-57-7

Suppliers and Price of 2,7-Dichloro-4-phenyl-1,8-naphthyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,7-Dichloro-4-phenyl-1,8-naphthyridine

Chemical Property:

XLogP3:5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:274.0064537
Heavy Atom Count:18
Complexity:281

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CC(=NC3=C2C=CC(=N3)Cl)Cl

Technology Process of 2,7-Dichloro-4-phenyl-1,8-naphthyridine

There total 7 articles about 2,7-Dichloro-4-phenyl-1,8-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 2,7-dihydroxy-4-phenyl-1,8-naphthyridine

: 58035-57-7
2,7-dichloro-4-phenyl-1,8-naphthyridine

Guidance literature:: With phosphorus pentachloride; trichlorophosphate; for 2.5h; Reflux;
DOI:10.1055/s-0034-1378384

Reference yield:

: 53734-97-7
4-phenyl-1H,8H-[1,8]naphthyridine-2,7-dione

: 58035-57-7
2,7-dichloro-4-phenyl-1,8-naphthyridine

Guidance literature:: With phosphorus pentachloride; at 135 ℃;

Reference yield:

: 141-86-6
2.6-diaminopyridine

: 58035-57-7
2,7-dichloro-4-phenyl-1,8-naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 180 °C

2: NaNO₂; aqueous H₂SO₄

3: PCl₅ / 135 °C

With phosphorus pentachloride; sulfuric acid; sodium nitrite;