Cyclohexanecarboxylic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(methoxymethoxy)-2-[(1R)-1-[[( 4-methylphenyl)sulfonyl]oxy]-2-oxopropyl]-4-(phenylmethoxy)-, (1R,2R,3S,4S,6R)-

Base Information

Chemical Name:Cyclohexanecarboxylic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(methoxymethoxy)-2-[(1R)-1-[[( 4-methylphenyl)sulfonyl]oxy]-2-oxopropyl]-4-(phenylmethoxy)-, (1R,2R,3S,4S,6R)-
CAS No.:581060-42-6
Molecular Formula:C32H46O10SSi
Molecular Weight:650.863
Hs Code.:

Cyclohexanecarboxylic acid,
6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(methoxymethoxy)-2-[(1R)-1-[[(
4-methylphenyl)sulfonyl]oxy]-2-oxopropyl]-4-(phenylmethoxy)-,
(1R,2R,3S,4S,6R)-

Synonyms:

Suppliers and Price of Cyclohexanecarboxylic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(methoxymethoxy)-2-[(1R)-1-[[( 4-methylphenyl)sulfonyl]oxy]-2-oxopropyl]-4-(phenylmethoxy)-, (1R,2R,3S,4S,6R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Cyclohexanecarboxylic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(methoxymethoxy)-2-[(1R)-1-[[( 4-methylphenyl)sulfonyl]oxy]-2-oxopropyl]-4-(phenylmethoxy)-, (1R,2R,3S,4S,6R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Cyclohexanecarboxylic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(methoxymethoxy)-2-[(1R)-1-[[( 4-methylphenyl)sulfonyl]oxy]-2-oxopropyl]-4-(phenylmethoxy)-, (1R,2R,3S,4S,6R)-

There total 9 articles about Cyclohexanecarboxylic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(methoxymethoxy)-2-[(1R)-1-[[( 4-methylphenyl)sulfonyl]oxy]-2-oxopropyl]-4-(phenylmethoxy)-, (1R,2R,3S,4S,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 581060-41-5
(1S,2S,3S,4R,5R)-1-benzyloxy-5-(tert-butyldimethylsilyloxy)-2-methoxymethyloxy-3-[(R)-1'-(p-toluenesulfonyloxy)-2'-oxopropyl]-4-vinylcyclohexane

: 581060-42-6
(1R,2R,3S,4S,6R)-4-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-3-methoxymethoxy-2-[(R)-2-oxo-1-(toluene-4-sulfonyloxy)-propyl]-cyclohexanecarboxylic acid

Guidance literature:: (1S,2S,3S,4R,5R)-1-benzyloxy-5-(tert-butyldimethylsilyloxy)-2-methoxymethyloxy-3-[(R)-1'-(p-toluenesulfonyloxy)-2'-oxopropyl]-4-vinylcyclohexane; With ozone; In methanol;

With sodium chlorite; sodium dihydrogenphosphate; amidosulfuric acid fluoride; In water; tert-butyl alcohol;
DOI:10.1016/S0040-4039(03)01186-9

Reference yield:

: Toluene-4-sulfonic acid (R)-1-[(1R,2S,3S,5R,6R)-3-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-6-formyl-2-methoxymethoxy-cyclohexyl]-2-oxo-propyl ester

: 581060-42-6
(1R,2R,3S,4S,6R)-4-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-3-methoxymethoxy-2-[(R)-2-oxo-1-(toluene-4-sulfonyloxy)-propyl]-cyclohexanecarboxylic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; amidosulfuric acid fluoride; In water; tert-butyl alcohol; at 20 ℃; for 10h;
DOI:10.1016/j.tet.2006.04.079

Reference yield:

: 581060-36-8
(2S,4R)-2-benzyloxy-4-(tert-butyldimethylsilyloxy)-5-hydroxy-cyclohexan-1-one

: 581060-42-6
(1R,2R,3S,4S,6R)-4-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-3-methoxymethoxy-2-[(R)-2-oxo-1-(toluene-4-sulfonyloxy)-propyl]-cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: MsCl; Et₃N / CH₂Cl₂ / 2.5 h / 0 °C

1.2: 3.50 g / HCl / H₂O

2.1: copper(I) cyanide / diethyl ether / -78 - 0 °C

2.2: diethyl ether / 0.5 h / -78 °C

2.3: 85 percent / diethyl ether / 0.33 h / -78 °C

3.1: 70 percent / Me₄NBH(OAc)3; acetic acid / tetrahydrofuran / 24 h / 0 - 20 °C

4.1: 100 percent / BuLi / tetrahydrofuran; hexane / 0.33 h / 0 °C

5.1: 98 percent / i-Pr₂NEt / 1,2-dichloro-ethane / 3.5 h / 50 °C

6.1: 97 percent / DDQ / CH₂Cl₂; H₂O / 1 h / 0 - 20 °C

7.1: 100 percent / Dess-Martin periodinane / CH₂Cl₂ / 23 h / 0 - 20 °C

8.1: ozone / methanol / 0.17 h / -78 °C

8.2: Me₂S / methanol / 3 h / -78 - 20 °C

9.1: 308 mg / NaH₂PO₄*H₂O; HOSO₂NH₂; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 10 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; amidosulfuric acid fluoride; copper(l) cyanide; Dess-Martin periodane; ozone; acetic acid; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; 1,2-dichloro-ethane; tert-butyl alcohol;
DOI:10.1016/j.tet.2006.04.079