2,3-dihydro-1H-3a,7a-epoxyindene

Base Information

• Chemical Name: 2,3-dihydro-1H-3a,7a-epoxyindene
• CAS No.: 1488-21-7
• Molecular Formula: C₉H₁₀O
• Molecular Weight: 134.178
• Mol file: 1488-21-7.mol

Synonyms:Indan,3a,7a-epoxy-3a,7a-dihydro- (7CI,8CI); 8,9-Indan oxide; Indan-3a,7a-oxide;Indane 3a,7a-oxide

Chemical Property of 2,3-dihydro-1H-3a,7a-epoxyindene

Chemical Property:

• Vapor Pressure: 0.102mmHg at 25°C
• Boiling Point: 230°Cat760mmHg
• Flash Point: 88.6°C
• Density: 1.16g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-dihydro-1H-3a,7a-epoxyindene

There total 4 articles about 2,3-dihydro-1H-3a,7a-epoxyindene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

trans-3,4-dibromo-10-oxatricyclo<4.3.1.01,6>decane (137053-62-4) → 8,9-Indanoxid (1488-21-7)

Guidance literature:

With potassium tert-butylate; In diethyl ether; at 0 ℃; for 1h;

Reference yield:

5,6-dibromohexahydro-1H-3a,7a-epoxyindene → 8,9-Indanoxid (1488-21-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; at 20 ℃; for 24h;

DOI:10.1021/acs.joc.8b00523

Reference yield:

2,3,4,7-tetrahydro-1H-3a,7a-epoxyindene (4471-30-1) → 8,9-Indanoxid (1488-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / Br₂ / CHCl₃ / -50 °C

2: 91 percent / potassium tert-butoxide / diethyl ether / 1 h / 0 °C

With potassium tert-butylate; bromine; In diethyl ether; chloroform;

upstream raw materials:

trans-3,4-dibromo-10-oxatricyclo<4.3.1.0^1,6>decane

2,3,4,7-tetrahydro-indene

2,3,4,7-tetrahydro-1H-3a,7a-epoxyindene

Downstream raw materials:

bicyclo [4.3.0]-2-methyl-nona-3,5-dien-1-ol

C₁₉H₁₇NO₃

Refernces

• 1、 Gillard, James R.,Newlands, Michael J.,Bridson, John N.,Burnell, D. Jean. "?-Facial stereoselectivity in the Diels-Alder reactions of benzene oxides". . p. 1337 - 1343. Retrieved 2007/10/02.