2-Pyrrolidinone, 5-[(S)-[[(1,1-dimethylethyl)dimethylsilyl]oxy][(4R,5S)-5-(hydroxymethyl)-2 ,2-dimethyl-1,3-dioxolan-4-yl]methyl]-1-(phenylmethyl)-, (5R)-

Base Information

Chemical Name:2-Pyrrolidinone, 5-[(S)-[[(1,1-dimethylethyl)dimethylsilyl]oxy][(4R,5S)-5-(hydroxymethyl)-2 ,2-dimethyl-1,3-dioxolan-4-yl]methyl]-1-(phenylmethyl)-, (5R)-
CAS No.:583040-19-1
Molecular Formula:C24H39NO5Si
Molecular Weight:449.663
Hs Code.:

2-Pyrrolidinone,
5-[(S)-[[(1,1-dimethylethyl)dimethylsilyl]oxy][(4R,5S)-5-(hydroxymethyl)-2
,2-dimethyl-1,3-dioxolan-4-yl]methyl]-1-(phenylmethyl)-, (5R)-

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Chemical Property of 2-Pyrrolidinone, 5-[(S)-[[(1,1-dimethylethyl)dimethylsilyl]oxy][(4R,5S)-5-(hydroxymethyl)-2 ,2-dimethyl-1,3-dioxolan-4-yl]methyl]-1-(phenylmethyl)-, (5R)-

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Technology Process of 2-Pyrrolidinone, 5-[(S)-[[(1,1-dimethylethyl)dimethylsilyl]oxy][(4R,5S)-5-(hydroxymethyl)-2 ,2-dimethyl-1,3-dioxolan-4-yl]methyl]-1-(phenylmethyl)-, (5R)-

There total 6 articles about 2-Pyrrolidinone, 5-[(S)-[[(1,1-dimethylethyl)dimethylsilyl]oxy][(4R,5S)-5-(hydroxymethyl)-2 ,2-dimethyl-1,3-dioxolan-4-yl]methyl]-1-(phenylmethyl)-, (5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 583039-98-9
(1'S,4''S,5R,5''S)-1-benzyl-5-[(benzyloxymethyl-2,2-dimethyl-[1,3]-dioxolan-4-yl)-(tert-butyldimethylsilanyloxy)methyl]pyrrolidin-2-one

: 583040-19-1
(R)-1-Benzyl-5-[(S)-(tert-butyl-dimethyl-silanyloxy)-((4R,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-pyrrolidin-2-one

Guidance literature:: With hydrogen; sodium acetate; palladium dihydroxide; In methanol; at 20 ℃; for 24h;
DOI:10.1021/jo0344539

Reference yield:

: 81028-12-8
(4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-5-carboxaldehyde

: 583040-19-1
(R)-1-Benzyl-5-[(S)-(tert-butyl-dimethyl-silanyloxy)-((4R,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / SnCl₄ / diethyl ether; CH₂Cl₂ / 5 h / -80 °C

2: 92 percent / NaBH₄; NiCl₂*6H₂O / methanol / 0.67 h / 0 °C

3: 90 percent / 2,6-lutidine / CH₂Cl₂ / 4 h / Heating

4: 98 percent / ceric ammonium nitrate / acetonitrile / 2 h / Heating

5: 70 percent / KH / tetrahydrofuran; various solvent(s) / 6 h / 60 °C

6: 80 percent / H₂; NaOAc / palladium hydroxyde / methanol / 24 h / 20 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; ammonium cerium(IV) nitrate; hydrogen; sodium acetate; tin(IV) chloride; potassium hydride; nickel dichloride; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jo0344539

Reference yield:

: 141293-20-1
(1'S,2R,4''S,5''S)-2-[(benzyloxymethyl-2,2-dimethyl-[1,3]-dioxolan-4-yl)hydroxymethyl]-5-oxo-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester

: 583040-19-1
(R)-1-Benzyl-5-[(S)-(tert-butyl-dimethyl-silanyloxy)-((4R,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / NaBH₄; NiCl₂*6H₂O / methanol / 0.67 h / 0 °C

2: 90 percent / 2,6-lutidine / CH₂Cl₂ / 4 h / Heating

3: 98 percent / ceric ammonium nitrate / acetonitrile / 2 h / Heating

4: 70 percent / KH / tetrahydrofuran; various solvent(s) / 6 h / 60 °C

5: 80 percent / H₂; NaOAc / palladium hydroxyde / methanol / 24 h / 20 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; ammonium cerium(IV) nitrate; hydrogen; sodium acetate; potassium hydride; nickel dichloride; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo0344539