Menaquinone 6

Base Information

• Chemical Name: Menaquinone 6
• CAS No.: 84-81-1
• Deprecated CAS: 13319-10-3
• Molecular Formula: C41H56O2
• Molecular Weight: 580.894
• UNII: 71ANL51TLA
• DSSTox Substance ID: DTXSID801018975
• Nikkaji Number: J1.591.794F,J10.613E
• Wikidata: Q27265949
• Metabolomics Workbench ID: 29108
• Mol file: 84-81-1.mol

Synonyms:2-methyl-3-farnesyl-farnesyl-1,4-naphthoquinone;menaquinone 6;MK-6

Chemical Property of Menaquinone 6

Chemical Property:

• Vapor Pressure: 5.49E-18mmHg at 25°C
• Melting Point: 49-50oC
• Refractive Index: 1.533
• Boiling Point: 673.3oC at 760 mmHg
• Flash Point: 240.7oC
• PSA: 34.14000
• Density: 0.97
• LogP: 12.37090
• Storage Temp.: −20°C
• XLogP3: 12.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 17
• Exact Mass: 580.42803102
• Heavy Atom Count: 43
• Complexity: 1160

Purity/Quality:

98%Min ^*data from raw suppliers

Menaquinone6 ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
• Isomeric SMILES: CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C
• Recent ClinicalTrials: Vitamin K2 Supplementation and Vascular Calcification
• Uses: Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a vari ety of physiological processes. Menaquinone-6 were the major isoprenoid quinones found in membrane preparations of Campylobacter jejuni and Campylobacter fetus. Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone-6 were the major isoprenoid quinones found in membrane preparations of Campylobacter jejuni and Campylobacter fetus.

Technology Process of Menaquinone 6

There total 28 articles about Menaquinone 6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-((2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl)-1,4-dimethoxy-3-methylnaphthalene → farnoquinone (84-81-1)

Guidance literature:

2-((2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl)-1,4-dimethoxy-3-methylnaphthalene; With ammonium cerium (IV) nitrate; In dichloromethane; acetonitrile; at -15 ℃; for 0.833333h; Inert atmosphere;

With water; In dichloromethane; acetonitrile; at 0 ℃;

DOI:10.1016/j.tet.2020.131696

Reference yield: 20.0%

C47H60O4S → farnoquinone (84-81-1)

Guidance literature:

C₄₇H₆₀O₄S; With (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride; In toluene; at 0 ℃; for 0.333333h;

With ammonium cerium (IV) nitrate; In dichloromethane; water; acetonitrile; at 0 ℃; for 1h;

Reference yield:

C46H62O2 → farnoquinone (84-81-1)

Guidance literature:

C₄₆H₆₂O₂; In ethyl acetate; at 78 ℃; for 1h;

With ammonium cerium (IV) nitrate; In dichloromethane; water; acetonitrile; at 0 ℃; for 1h; Solvent;

upstream raw materials:

2-methyl-1,4-naphthohydroquinone

8-hydroxygeranyl acetate

3,7-dimethyl-8-chloro-2(E),6(E)-octadien-1-yl acetate

Farnesol

Downstream raw materials:

1,4-diacetoxy-2-(3,7,11,15,19,23-hexamethyl-tetracosa-2t,6t,10t,14t,18t,22-hexaenyl)-3-methyl-naphthalene