1(2H)-Isoquinolinone, 3-acetyl-2-[(4-acetylphenyl)methyl]-6-bromo-4-phenyl-

Base Information

Chemical Name:1(2H)-Isoquinolinone, 3-acetyl-2-[(4-acetylphenyl)methyl]-6-bromo-4-phenyl-
CAS No.:583836-31-1
Molecular Formula:C26H20BrNO3
Molecular Weight:474.354
Hs Code.:

Synonyms:

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Chemical Property of 1(2H)-Isoquinolinone, 3-acetyl-2-[(4-acetylphenyl)methyl]-6-bromo-4-phenyl-

Chemical Property:

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Technology Process of 1(2H)-Isoquinolinone, 3-acetyl-2-[(4-acetylphenyl)methyl]-6-bromo-4-phenyl-

There total 8 articles about 1(2H)-Isoquinolinone, 3-acetyl-2-[(4-acetylphenyl)methyl]-6-bromo-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1
benzene

: 583836-31-1
3-acetyl-2-(4-acetylbenzyl)-6-bromo-4-phenyl-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: aluminum (III) chloride / 1.5 h / 20 °C / Heating / reflux

1.2: 0.5 h / 20 °C

2.1: potassium carbonate / acetone / 0.17 h / 20 °C

3.1: DMF (N,N-dimethyl-formamide); acetone / 20 h / 20 °C

3.2: 15 h / 120 °C

4.1: dmap; cycl-isopropylidene malonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 15 h / 20 °C

4.2: 10 h / Heating / reflux

5.1: triethylamine / methanol / 18 h / 20 °C

5.2: 10 h / 20 °C

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 12 h / 20 °C

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 15 h / 20 °C

8.1: tetrahydrofuran / 2 h / 0 °C

With dmap; aluminum (III) chloride; sodium hydroxide; cycl-isopropylidene malonate; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); dichloromethane; acetone;

Reference yield:

: 4-bromo-2-benzoylbenzoic acid potassium salt

: 583836-31-1
3-acetyl-2-(4-acetylbenzyl)-6-bromo-4-phenyl-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: DMF (N,N-dimethyl-formamide); acetone / 20 h / 20 °C

1.2: 15 h / 120 °C

2.1: dmap; cycl-isopropylidene malonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 15 h / 20 °C

2.2: 10 h / Heating / reflux

3.1: triethylamine / methanol / 18 h / 20 °C

3.2: 10 h / 20 °C

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 12 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 15 h / 20 °C

6.1: tetrahydrofuran / 2 h / 0 °C

With dmap; sodium hydroxide; cycl-isopropylidene malonate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); dichloromethane; acetone;

Reference yield:

: 583838-05-5
3-acetyl-6-bromo-4-phenyl-isochromen-1-one

: 583836-31-1
3-acetyl-2-(4-acetylbenzyl)-6-bromo-4-phenyl-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / methanol / 18 h / 20 °C

1.2: 10 h / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 12 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 15 h / 20 °C

4.1: tetrahydrofuran / 2 h / 0 °C

With sodium hydroxide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;