Prostaglandin D2 1,9-lactone

Base Information

Chemical Name:Prostaglandin D2 1,9-lactone
CAS No.:62410-93-9
Molecular Formula:C20H30O4
Molecular Weight:334.4498
Hs Code.:
Mol file:62410-93-9.mol

Synonyms:PGD2 1,9-lactone;Prostaglandin D2 1,9-lactone;BRN 4325977;BRN 5577723;Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, lambda-lactone, (5Z,11-alpha,13E,15S)-;Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, theta-lactone, (5Z,9-alpha,13E,15S)-;LS-125825;LS-125826

Suppliers and Price of Prostaglandin D2 1,9-lactone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
PROSTAGLANDIN E2 1,15-LACTONE 95.00%
5MG
$ 499.80

Total 0 raw suppliers

Chemical Property of Prostaglandin D2 1,9-lactone

Chemical Property:

Vapor Pressure:4.58E-12mmHg at 25°C
Boiling Point:499.4°Cat760mmHg
Flash Point:269.9°C
PSA：74.60000
Density:1.111g/cm³
LogP:4.05630
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:12
Exact Mass:334.21440943
Heavy Atom Count:24
Complexity:476

Purity/Quality:: PROSTAGLANDIN E2 1,15-LACTONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC(C=CC1C(C(=CC1=O)O)CC=CCCCC=O)O
Isomeric SMILES:CCCCC[C@@H](/C=C/[C@@H]1[C@H](C(=CC1=O)O)C/C=C\CCCC=O)O

Technology Process of Prostaglandin D2 1,9-lactone

There total 17 articles about Prostaglandin D2 1,9-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 276241-85-1
(3S,11aR,14R,14aR)-14-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}-3-pentyl-6,7,8,11,11a,13,14,14a-octahydro-3H-cyclopenta[e]oxacyclotridecine-5,12-dione

: 62410-93-9
PGE2-1,15-lactone

Guidance literature:: With hydrogen fluoride; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1002/(SICI)1521-3773(20000403)39:7<1234::AID-ANIE1234>3.0.CO;2-V

Reference yield: 74.0%

: 318234-63-8
(3S,11aR,14R,14aR)-14-hydroxy-3-pentyl-9,10-didehydro-6,7,8,11,11a,13,14,14a-octahydro-3H-cyclopenta[e]oxacyclotridecine-5,12-dione

: 62410-93-9
PGE2-1,15-lactone

Guidance literature:: With quinoline; hydrogen; Lindlar's catalyst; under 760.051 Torr;
DOI:10.1021/ja003119g

Reference yield:

: 276241-82-8
(2R,3R,4R)-4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}-2-(2-butynyl)-3-[(E,3S)-3-hydroxy-1-octenyl]cyclopentan-1-one

: 62410-93-9
PGE2-1,15-lactone

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / diisopropyl carbodiimide; DMAP / CH₂Cl₂ / 3 h / 20 °C

2: 77 percent / CH₂Cl₂ / Mo[N(t-Bu)(p-PhF)]3/CH₂Cl₂ / toluene / 16 h / 80 °C

3: 86 percent / H₂; quinoline / Lindlar catalyst / hexane / 2 h / 760.05 Torr

4: 88 percent / aq. HF / acetonitrile / 1 h

With quinoline; dmap; dichloromethane; hydrogen fluoride; hydrogen; diisopropyl-carbodiimide; Lindlar's catalyst; dichloromethane; Mo[N(t-Bu)(p-PhF)]3; In hexane; dichloromethane; toluene; acetonitrile;
DOI:10.1021/ja003119g