(2S)-2-(3-methoxypentan-3-yl)pyrrolidin-1-amine

Base Information

• Chemical Name: (2S)-2-(3-methoxypentan-3-yl)pyrrolidin-1-amine
• CAS No.: 118535-62-9
• Molecular Formula: C10H22 N2 O
• Molecular Weight: 186.297
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID001227839
• Nikkaji Number: J1.081.278J
• Mol file: 118535-62-9.mol

Synonyms:118535-62-9;(2S)-2-(3-methoxypentan-3-yl)pyrrolidin-1-amine;(S)-(-)-AMINO-2-(1'-METHOXY-1'-ETHYLPROPYL)PYRROLIDINE;(S)-2-(3-Methoxypentan-3-yl)pyrrolidin-1-amine;(S)-1-AMINO-2-(DIETHYLMETHOXYMETHYL)PYRROLIDINE;DTXSID001227839;AKOS017343584;(S)-1-amino-2-(diethyl methoxymethyl)pyrrolidine;(2S)-1-Amino-2-(1-methoxy-1-ethylpropyl)pyrrolidine;(2S)-2-(1-Ethyl-1-methoxypropyl)-1-pyrrolidinamine;(s)-1-amino-2-(1-ethyl-1-methoxypropyl)pyrrolidine

Chemical Property of (2S)-2-(3-methoxypentan-3-yl)pyrrolidin-1-amine

Chemical Property:

• Refractive Index: 1.475-1.477
• Boiling Point: 249.6°Cat760mmHg
• Flash Point: 104.8°C
• PSA: 38.49000
• Density: g/cm³
• LogP: 2.16790
• Storage Temp.: -20°C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 186.173213330
• Heavy Atom Count: 13
• Complexity: 157

Purity/Quality:

98%min ^*data from raw suppliers

(S)-(-)-AMINO-2-(1'-METHOXY-1'-ETHYLPROPYL)PYRROLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(CC)(C1CCCN1N)OC
• Isomeric SMILES: CCC(CC)([C@@H]1CCCN1N)OC

Technology Process of (2S)-2-(3-methoxypentan-3-yl)pyrrolidin-1-amine

There total 7 articles about (2S)-2-(3-methoxypentan-3-yl)pyrrolidin-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(-)-1-benzyl-2-(1-hydroxy-1-ethylpropyl)-pyrrolidine (118970-93-7) → (S)-(-)-1-amino-2-(1'-methoxy-1'-ethylpropyl)pyrrolidine (118535-62-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 96.7 percent / NaH / tetrahydrofuran / -30 deg C to RT, reflux

2: 72 percent / H₂ / 10 percent Pd/C / ethanol / Ambient temperature

3: t-BuONO / tetrahydrofuran / Heating

4: LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; tert.-butylnitrite; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol;

Reference yield:

(S)-(-)-1-benzyl-2-(1-methoxy-1-ethylpropyl)-pyrrolidine (118970-97-1) → (S)-(-)-1-amino-2-(1'-methoxy-1'-ethylpropyl)pyrrolidine (118535-62-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / H₂ / 10 percent Pd/C / ethanol / Ambient temperature

2: t-BuONO / tetrahydrofuran / Heating

3: LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; tert.-butylnitrite; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

Reference yield:

N-benzyl-L-proline ethyl ester (955-40-8,172478-10-3) → (S)-(-)-1-amino-2-(1'-methoxy-1'-ethylpropyl)pyrrolidine (118535-62-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 94 percent / diethyl ether / 2 h / Heating

2: 96.7 percent / NaH / tetrahydrofuran / -30 deg C to RT, reflux

3: 72 percent / H₂ / 10 percent Pd/C / ethanol / Ambient temperature

4: t-BuONO / tetrahydrofuran / Heating

5: LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; tert.-butylnitrite; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol;

upstream raw materials:

(S)-2-(1-Ethyl-1-methoxy-propyl)-1-nitroso-pyrrolidine

(S)-(-)-2-(1-methoxy-1-ethylpropyl)-pyrrolidine

(S)-(-)-1-benzyl-2-(1-hydroxy-1-ethylpropyl)-pyrrolidine

(S)-(-)-1-benzyl-2-(1-methoxy-1-ethylpropyl)-pyrrolidine

Downstream raw materials:

[(S)-2-(1-Ethyl-1-methoxy-propyl)-pyrrolidin-1-yl]-[3-phenyl-prop-(Z)-ylidene]-amine

(S)-(+)-1-[1-(2,6-Di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-ethylideneamino]-2-(1-methoxy-1-ethylpropyl)pyrrolidine

[(S)-2-(1-Ethyl-1-methoxy-propyl)-pyrrolidin-1-yl]-[2-[((E)-hex-2-enyl)oxy]-cyclohex-(E)-ylidene]-amine

(S)-(+)-1-[1-(2,6-Di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-propylideneamino]-2-(1-methoxy-1-ethylpropyl)pyrrolidine