Technology Process of Quinoline,
5-[2-[4-[[3-(3-furanyl)phenyl]methyl]-1-piperidinyl]ethoxy]-2-methyl-
There total 5 articles about Quinoline,
5-[2-[4-[[3-(3-furanyl)phenyl]methyl]-1-piperidinyl]ethoxy]-2-methyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
10% palladium on activated carbon; hydrogen;
In
ethanol;
at 20 ℃;
for 24h;
DOI:10.1016/j.bmcl.2008.11.052
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogenchloride / diethyl ether / 72 h / 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C
3: palladium diacetate; potassium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / Reflux
4: 10% palladium on activated carbon; hydrogen / ethanol / 24 h / 20 °C
With
hydrogenchloride; 10% palladium on activated carbon; hydrogen; palladium diacetate; potassium carbonate; triphenylphosphine;
In
1,2-dimethoxyethane; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
3: Suzuki coupling;
DOI:10.1016/j.bmcl.2008.11.052
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C
2: palladium diacetate; potassium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / Reflux
3: 10% palladium on activated carbon; hydrogen / ethanol / 24 h / 20 °C
With
10% palladium on activated carbon; hydrogen; palladium diacetate; potassium carbonate; triphenylphosphine;
In
1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;
2: Suzuki coupling;
DOI:10.1016/j.bmcl.2008.11.052
