3-Guanylic acid, 2-deoxy-N-(2-methyl-1-oxopropyl)-, 4-chlorophenyl 2-cyanoethyl ester

Base Information

• Chemical Name: 3-Guanylic acid, 2-deoxy-N-(2-methyl-1-oxopropyl)-, 4-chlorophenyl 2-cyanoethyl ester
• CAS No.: 71002-59-0
• Molecular Formula: C23H26ClN6O8P
• Molecular Weight: 580.922

Synonyms:2'-deoxy-N-(2-methyl-1-oxopropyl)-3'-guanylic acid, 4-chlorophenyl 2-cyanoethyl ester;Phosphoric acid 4-chloro-phenyl ester 2-cyano-ethyl ester (2R,3S,5R)-2-hydroxymethyl-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester;

Chemical Property of 3-Guanylic acid, 2-deoxy-N-(2-methyl-1-oxopropyl)-, 4-chlorophenyl 2-cyanoethyl ester

Chemical Property:

• PSA: 200.49000
• LogP: 3.22288

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Guanylic acid, 2-deoxy-N-(2-methyl-1-oxopropyl)-, 4-chlorophenyl 2-cyanoethyl ester

There total 9 articles about 3-Guanylic acid, 2-deoxy-N-(2-methyl-1-oxopropyl)-, 4-chlorophenyl 2-cyanoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

Phosphoric acid 4-chloro-phenyl ester 2-cyano-ethyl ester (2R,3S,5R)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester (63660-22-0) → N2-isobutyryl-2'-deoxy-[3']guanylic acid 4-chloro-phenyl ester 2-cyano-ethyl ester (71002-59-0)

Guidance literature:

With acetic acid; for 4h;

DOI:10.1016/S0040-4039(01)81907-9

Reference yield:

5'-O-(dimethoxytrityl)-N-isobutyrylguanine 3'-(p-chlorophenylcyanoethyl phosphate) (71100-72-6) → N2-isobutyryl-2'-deoxy-[3']guanylic acid 4-chloro-phenyl ester 2-cyano-ethyl ester (71002-59-0)

Guidance literature:

With benzenesulfonic acid; In methanol; chloroform;

Reference yield:

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine (68892-41-1) → N2-isobutyryl-2'-deoxy-[3']guanylic acid 4-chloro-phenyl ester 2-cyano-ethyl ester (71002-59-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-methylimidazole / acetonitrile / 2 h / 20 °C

2: 2percent benzenesulfonic acid / CHCl₃; methanol

With 1-methyl-1H-imidazole; benzenesulfonic acid; In methanol; chloroform; acetonitrile;

upstream raw materials:

Phosphoric acid 4-chloro-phenyl ester 2-cyano-ethyl ester (2R,3S,5R)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester

5'-O-(dimethoxytrityl)-N-isobutyrylguanine 3'-(p-chlorophenylcyanoethyl phosphate)

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

(p-chlorophenyl) (β-cyanoethyl) phosphorochloridate

Downstream raw materials:

5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(4-chlorophenyl)thymidylyl-(3'->5')-2'-deoxy-N-(2-methyl-1-oxopropyl)-3'-guanylic acid, 4-chlorophenyl 2-cyanoethyl ester

C₆₄H₆₅Cl₂N₁₁O₁₇P₂

C₃₉H₄₂Cl₂N₈O₁₅P₂

C₄₃H₄₇Cl₂N₁₁O₁₅P₂

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 71002-59-0 3-Guanylic acid, 2-deoxy-N-(2-methyl-1-oxopropyl)-, 4-chlorophenyl 2-cyanoethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send