Rapacuronium bromide

Base Information

• Chemical Name: Rapacuronium bromide
• CAS No.: 156137-99-4
• Molecular Formula: C37H61BrN2O4
• Molecular Weight: 677.803
• European Community (EC) Number: 685-612-1
• UNII: 65Q4QDG4KC
• DSSTox Substance ID: DTXSID7048823
• Wikipedia: Rapacuronium_bromide
• Wikidata: Q3419354
• NCI Thesaurus Code: C66509
• ChEMBL ID: CHEMBL1200549
• Mol file: 156137-99-4.mol

Synonyms:Org 9487;Org-9487;rapacuronium;rapacuronium bromide;Raplon

Chemical Property of Rapacuronium bromide

Chemical Property:

• Melting Point: 184°
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 55.84000
• Density: g/cm³
• LogP: 3.81290
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 9
• Exact Mass: 676.38147
• Heavy Atom Count: 44
• Complexity: 1030

Purity/Quality:

97% ^*data from raw suppliers

RapacuroniumBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)OC1C(CC2C1(CCC3C2CCC4C3(CC(C(C4)OC(=O)C)N5CCCCC5)C)C)[N+]6(CCCCC6)CC=C.[Br-]
• Isomeric SMILES: CCC(=O)O[C@H]1[C@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(C[C@@H]([C@H](C4)OC(=O)C)N5CCCCC5)C)C)[N+]6(CCCCC6)CC=C.[Br-]
• Description: Rapacuronium bromide was introduced in the US as a parenterally administered adjunct to general anesthesia during surgical procedures. It is a new steroidal derivative belonging to the same class as vecuronium bromide. This 2,16-bispiperidinylandrostane derivative can be synthesized in 3 steps from the 3-hydroxy-androstan-17-one analog and finally quaternized with allyl bromide. Rapacuronium bromide is a nondepolarizing neuromuscular blocking drug with a rapid onset and a short duration of action. With a relatively low potency (ED90 = 1.15 mg/kg), Rapacuronium is expected to be substituted for the polarizing succinylcholine with very short duration of action.
• Uses: Rapacuronium Bromide is an aminosteroidal nondepolarizing neuromuscular blocking agent and was used as a anesthesia.

Technology Process of Rapacuronium bromide

There total 2 articles about Rapacuronium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ rapacuronium bromide (156137-99-4)

Guidance literature:

Reference yield:

→ 1-[(2β, 3α, 5α, 16β, 17α)-3-(acetyloxy)-17-(1-oxopropoxy)-2-(1-piperidinyl)-androstan-16-yl]-1-methylpiperidinium bromide + 1-[(2β, 3α, 5α, 16β, 17α)-3-(acetyloxy)-17-(1-oxopropoxy)-2-(1-piperidinyl)-androstan-16-yl]-1-(2-propenyl) piperidinium bromide (156137-99-4)

Guidance literature: