1H-Pyrrolizine-5-acetic acid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-, 4-(nitrooxy)butyl ester

Base Information

Chemical Name:1H-Pyrrolizine-5-acetic acid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-, 4-(nitrooxy)butyl ester
CAS No.:586347-53-7
Molecular Formula:C₂₇H₂₉ClN₂O₅
Molecular Weight:496.991
Hs Code.:

Synonyms:

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Chemical Property of 1H-Pyrrolizine-5-acetic acid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-, 4-(nitrooxy)butyl ester

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Technology Process of 1H-Pyrrolizine-5-acetic acid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-, 4-(nitrooxy)butyl ester

There total 8 articles about 1H-Pyrrolizine-5-acetic acid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-, 4-(nitrooxy)butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.1%

: 912341-47-0
4-bromobutyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate

: 586347-53-7
4-(nitrooxy)butyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate

Guidance literature:: With silver nitrate; In acetonitrile; Reflux;
DOI:10.1002/ardp.201000397

Reference yield:

: 100-44-7
benzyl chloride

: 586347-53-7
4-(nitrooxy)butyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: magnesium

1.2: 5 h / Reflux

2.1: sodium hydrogencarbonate / ethanol; water / 36 h / 20 °C

3.1: tetrahydrofuran / 10 - 15 °C

4.1: water / tetrahydrofuran / 0.33 h / 25 - 30 °C

5.1: hydrazine hydrate; potassium hydroxide / diethylene glycol / 7 h / 85 - 145 °C

6.1: potassium carbonate / acetone / 56 °C

7.1: silver nitrate / acetonitrile / Reflux

With water; sodium hydrogencarbonate; potassium carbonate; hydrazine hydrate; silver nitrate; magnesium; potassium hydroxide; In tetrahydrofuran; ethanol; water; acetone; acetonitrile; diethylene glycol; 3.1: Friedel Crafts acylation / 5.1: Wolff-Kishner reduction;
DOI:10.1002/ardp.201000397

Reference yield:

: 1310936-45-8
C₂₃H₁₉Cl₂NO₂

: 586347-53-7
4-(nitrooxy)butyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: water / tetrahydrofuran / 0.33 h / 25 - 30 °C

2: hydrazine hydrate; potassium hydroxide / diethylene glycol / 7 h / 85 - 145 °C

3: potassium carbonate / acetone / 56 °C

4: silver nitrate / acetonitrile / Reflux

With water; potassium carbonate; hydrazine hydrate; silver nitrate; potassium hydroxide; In tetrahydrofuran; acetone; acetonitrile; diethylene glycol; 2: Wolff-Kishner reduction;
DOI:10.1002/ardp.201000397