Piperazinone, 1-methyl-4-[3-[[1-[2-[(2-methyl-5-quinolinyl)oxy]ethyl]-4-piperidinylidene] methyl]phenyl]-

Base Information

Chemical Name:Piperazinone, 1-methyl-4-[3-[[1-[2-[(2-methyl-5-quinolinyl)oxy]ethyl]-4-piperidinylidene] methyl]phenyl]-
CAS No.:586412-59-1
Molecular Formula:C₂₉H₃₄N₄O₂
Molecular Weight:470.615
Hs Code.:

Synonyms:

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Chemical Property of Piperazinone, 1-methyl-4-[3-[[1-[2-[(2-methyl-5-quinolinyl)oxy]ethyl]-4-piperidinylidene] methyl]phenyl]-

Chemical Property:

Purity/Quality:

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Technology Process of Piperazinone, 1-methyl-4-[3-[[1-[2-[(2-methyl-5-quinolinyl)oxy]ethyl]-4-piperidinylidene] methyl]phenyl]-

There total 5 articles about Piperazinone, 1-methyl-4-[3-[[1-[2-[(2-methyl-5-quinolinyl)oxy]ethyl]-4-piperidinylidene] methyl]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 163210-03-5
tert-butyl 4-[(3-bromophenyl)methylene]piperidine-1-carboxylate

: 586412-59-1
C₂₉H₃₄N₄O₂

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / diethyl ether / 72 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

3: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / Reflux

With hydrogenchloride; palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2008.11.052

Reference yield:

: 584555-96-4
C₁₂H₁₄BrN

: 586412-59-1
C₂₉H₃₄N₄O₂

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

2: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / Reflux

With palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2008.11.052

Reference yield:

: 823-78-9
meta-bromobenzyl bromide

: 586412-59-1
C₂₉H₃₄N₄O₂

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 24 h / Reflux

2: sodium hydride / tetrahydrofuran / 4 h / 20 °C

3: hydrogenchloride / diethyl ether / 72 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

5: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / Reflux

With hydrogenchloride; palladium diacetate; sodium hydride; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide; toluene; 2: Horner-Wadsworth-Emmons coupling;
DOI:10.1016/j.bmcl.2008.11.052