Brn 6572492

Base Information

• Chemical Name: Brn 6572492
• CAS No.: 103602-95-5
• Molecular Formula: C₁₄H₁₅N₃O₂
• Molecular Weight: 257.292
• Mol file: 103602-95-5.mol

Synonyms:Benzo[h]cinnoline,acetamide deriv.

Chemical Property of Brn 6572492

Chemical Property:

• PSA: 70.56000
• LogP: 1.26880

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Brn 6572492

There total 13 articles about Brn 6572492 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

6-(acetylamino)-1,2,3,4-tetrahydro-1-oxonaphthalene-2-acetic acid (103602-78-4) → 8-Acetylamino-4,4a,5,6-tetrahydrobenzocinnolin-3(2H)-one (103602-95-5,103602-97-7,103422-56-6,121866-03-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Heating;

DOI:10.1021/jm00130a009

Reference yield: 85.0%

(+)-6-(acetylamino)-1,2,3,4-tetrahydro-1-oxonaphthalene-2-acetic acid (103602-89-7) → (-)-8-(acetylamino)-4,4a,5,6-tetrahydrobenzocinnolin-3(2H)-one (103602-95-5,121866-03-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Heating;

DOI:10.1021/jm00130a009

Reference yield: 12.0%

(6-acetamido-1-oxo-1,2,3,4-tetrahydronaphth-2-yl)acetamide (104107-19-9) → 8-Acetylamino-4,4a,5,6-tetrahydrobenzocinnolin-3(2H)-one (103602-95-5,103602-97-7,103422-56-6,121866-03-3)

Guidance literature:

With hydrazine hydrate; In acetic acid; for 0.5h; Heating;

DOI:10.1016/0223-5234(90)90196-A

upstream raw materials:

acetic anhydride

dl-8-amino-4,4a,5,6-tetrahydro-2H-benzo(h)-cinnolin-3-one

(6-acetamido-1-oxo-1,2,3,4-tetrahydronaphth-2-yl)acetamide

6-(acetylamino)-1,2,3,4-tetrahydro-1-oxonaphthalene-2-acetic acid

Downstream raw materials:

8-cyano-4,4a,5,6-tetrahydrobenzocinnolin-3<2H>-one

8-[(2-chloropropionyl)amino]-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-one