Chemical Property of thielavin A
Chemical Property:
- Vapor Pressure:9.92E-31mmHg at 25°C
- Boiling Point:850°C at 760 mmHg
- Flash Point:281°C
- PSA：170.82000
- Density:1.371g/cm3
- LogP:5.11280
- Purity/Quality:
-
99% *data from raw suppliers
Thielavin A *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
-
Description
Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 (PGH2; ) and the conversion of PGH2 to PGE2 (; IC50s = 10 and 40 μM, respectively). Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 μM; Ki = 27.8 μM).
-
Uses
The fungal metabolite, thielavin A, and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor. Thielavin A acts as an inhibitor of prostagladins biosynthesis.
