7a-hydroxy-3-methyl-5,6,7,7a-tetrahydro-1-benzofuran-2(4H)-one

Base Information

• Chemical Name: 7a-hydroxy-3-methyl-5,6,7,7a-tetrahydro-1-benzofuran-2(4H)-one
• CAS No.: 15210-14-7
• Molecular Formula: C₉H₁₂O₃
• Molecular Weight: 168.192
• Mol file: 15210-14-7.mol

Synonyms:NSC 361587

Chemical Property of 7a-hydroxy-3-methyl-5,6,7,7a-tetrahydro-1-benzofuran-2(4H)-one

Chemical Property:

• Vapor Pressure: 7.54E-07mmHg at 25°C
• Boiling Point: 366.2°Cat760mmHg
• Flash Point: 168.8°C
• Density: 1.25g/cm³

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7a-hydroxy-3-methyl-5,6,7,7a-tetrahydro-1-benzofuran-2(4H)-one

There total 16 articles about 7a-hydroxy-3-methyl-5,6,7,7a-tetrahydro-1-benzofuran-2(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trimethyl(3-methyl-4,5,6,7-tetrahydro-benzofuran-2-yl)silane (591231-64-0) → (RS)-3-methyl-7a-hydroxy-4,5,6,7-tetrahydro-7aH-benzofuran-2-one (15210-14-7)

Guidance literature:

With oxygen; rose bengal; In methanol; at -78 ℃; Irradiation;

DOI:10.1016/S0040-4039(03)01172-9

Reference yield: 45.0%

tert-butyl-dimethyl-(3-methyl-4,5,6,7-tetrahydro-benzofuran-2-yloxy)-silane (862015-57-4) → (RS)-3-methyl-7a-hydroxy-4,5,6,7-tetrahydro-7aH-benzofuran-2-one (15210-14-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2005.04.125

Reference yield: 38.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 2-oxo-propionic acid (127-17-3) → (RS)-3-methyl-7a-hydroxy-4,5,6,7-tetrahydro-7aH-benzofuran-2-one (15210-14-7)

Guidance literature:

In phosphoric acid; at 80 ℃; for 4h;

DOI:10.1002/hlca.19810640733

upstream raw materials:

cyclohexanone

2-oxo-propionic acid

2,4,5,6,7,7a-Hexahydro-3-methyl-1-benzofuran-2-on

acide α-(ceto-2 cyclohexyle)-lactique