N-Cbz4-(4-hydroxyphenyl)butylamine

Base Information

Chemical Name:N-Cbz4-(4-hydroxyphenyl)butylamine
CAS No.:587880-25-9
Molecular Formula:C18H21NO3
Molecular Weight:299.37
Hs Code.:
DSSTox Substance ID:DTXSID80469853
Wikidata:Q82297754

Synonyms:N-Cbz4-(4-hydroxyphenyl)butylamine;587880-25-9;Benzyl N-[4-(4-hydroxyphenyl)butyl]carbamate;SCHEMBL917677;DTXSID80469853;JJXKVLJSXQXDGJ-UHFFFAOYSA-N;N-Cbz-4-(4-Hydroxyphenyl)butylamine;4-[4-(benzyloxycarbonylamino)butyl]phenol;Benzyl(4-(4-hydroxyphenyl)butyl)carbamate;Benzyl (4-(4-hydroxyphenyl)butyl)carbamate;[4-(4-hydroxyphenyl)butyl]carbamic acid benzyl ester

Suppliers and Price of N-Cbz4-(4-hydroxyphenyl)butylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of N-Cbz4-(4-hydroxyphenyl)butylamine

Chemical Property:

PSA：62.05000
LogP:3.84570
XLogP3:3.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:299.15214353
Heavy Atom Count:22
Complexity:308

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC(=O)NCCCCC2=CC=C(C=C2)O

Technology Process of N-Cbz4-(4-hydroxyphenyl)butylamine

There total 9 articles about N-Cbz4-(4-hydroxyphenyl)butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 4-(4-hydroxyphenyl)butylamine hydrobromide

: 501-53-1,94274-21-2
benzyl chloroformate

: 587880-25-9
4-(4-hydroxyphenyl)butylcarbamic acid benzyl ester

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

: 123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6
1,4-dioxane

: 4-(4-hydroxyphenyl)butylamine hydrobromide

: 587880-25-9
4-(4-hydroxyphenyl)butylcarbamic acid benzyl ester

Guidance literature:: With sodium hydrogencarbonate; In water; toluene;

Reference yield:

: 4521-28-2
4-(4-Methoxyphenyl)butyric acid

: 587880-25-9
4-(4-hydroxyphenyl)butylcarbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methylmorpholine; isobutylchloroformate / tetrahydrofuran / 0.5 h / -20 - -10 °C

1.2: 97 percent / NH₃ / methanol; tetrahydrofuran

2.1: borane / tetrahydrofuran / 3 h / Heating

3.1: 90 percent / aq. HBr / 3 h / Heating

4.1: 62 percent / sodium bicarbonate / dioxane; H₂O / -2 - 20 °C

With 4-methyl-morpholine; borane; hydrogen bromide; sodium hydrogencarbonate; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jm051134w