(R)-tert-butyl 1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropylcarbamate
CAS No.:587881-33-2
Molecular Formula:C₂₄H₂₈ClN₃O₃
Molecular Weight:441.958
Hs Code.:
Mol file:587881-33-2.mol

Synonyms:QC-8171;

Suppliers and Price of (R)-tert-butyl 1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of (R)-tert-butyl 1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropylcarbamate

Chemical Property:

PSA：76.71000
Density:1.21
LogP:5.52440

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-tert-butyl 1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropylcarbamate

There total 4 articles about (R)-tert-butyl 1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 587881-37-6
C₁₇H₂₁ClN₂O₄

: 100-46-9
benzylamine

: 587881-33-2
tert-butyl (R)-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)carbamate

Guidance literature:: at 20 - 180 ℃; for 0.05h; Temperature; Time; Microwave irradiation;

Reference yield:

: 22838-58-0
Boc-D-Val-OH

: 89-77-0
2-Amino-4-chlorobenzoic acid

: 587881-33-2
tert-butyl (R)-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper dichloride; methanesulfonyl chloride; 1-methyl-1H-imidazole / 1,2-dichloro-ethane / 1 h / -20 °C / Molecular sieve; Inert atmosphere

1.2: 1.5 h / -20 °C / Molecular sieve; Inert atmosphere

1.3: 1.5 h / -20 - 40 °C / Molecular sieve; Inert atmosphere

2.1: copper dichloride; methanesulfonyl chloride; 1-methyl-1H-imidazole / 1,2-dichloro-ethane / 16 h / Molecular sieve; Inert atmosphere; Reflux

With 1-methyl-1H-imidazole; methanesulfonyl chloride; copper dichloride; In 1,2-dichloro-ethane;
DOI:10.1002/adsc.202001279

Reference yield:

: 89-77-0
2-Amino-4-chlorobenzoic acid

: 587881-33-2
tert-butyl (R)-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; triphenyl phosphite / 0.12 h / 150 °C / Microwave irradiation

2: 0.05 h / 20 - 180 °C / Microwave irradiation

With pyridine; triphenyl phosphite;