2-Chloro-5-(trifluoroMethoxy)nitrobenzene

Base Information

• Chemical Name: 2-Chloro-5-(trifluoroMethoxy)nitrobenzene
• CAS No.: 588-09-0
• Molecular Formula: C7H3ClF3NO3
• Molecular Weight: 241.554
• Hs Code.: 2909309090
• Mol file: 588-09-0.mol

Synonyms:2-chloro-4-trifluoromethoxy nitrobenzene;4-Chlor-3-nitro-1-trifluormethoxy-benzol;Trifluormethyl-<4-chlor-3-nitro-phenyl>-aether;4-chloro-3-nitro-trifluoromethoxybenzene;1-chloro-2-nitro-4-trifluoromethoxybenzene;

Chemical Property of 2-Chloro-5-(trifluoroMethoxy)nitrobenzene

Chemical Property:

• Boiling Point: 247℃
• Flash Point: 103℃
• PSA: 55.05000
• Density: 1.572
• LogP: 3.67000
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Chloro-2-nitro-4-(trifluoromethoxy)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-5-(trifluoroMethoxy)nitrobenzene

There total 5 articles about 2-Chloro-5-(trifluoroMethoxy)nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.6%

→ 4-chloro-2-nitro-1-(trifluoromethoxy)benzene (448-38-4) + 4-(trifluoromethoxy)-2-nitro-1-chlorobenzene (588-09-0)

Guidance literature:

With magnesium(II) perchlorate; 2-nitrobenzo[d]isothiazol-3(2H)-one 1,1-dioxide; In [D₃]acetonitrile; at 85 ℃; for 5h; Overall yield = 97 percent; Inert atmosphere; Sealed tube;

Reference yield: 41.0%

silver(I) trifluoromethoxide (1006904-72-8) + 3-nitro-4-chlorophenyldiazonium tetrafluoroborate → 4-(trifluoromethoxy)-2-nitro-1-chlorobenzene (588-09-0)

Guidance literature:

In acetonitrile; at -40 ℃; for 2h; Inert atmosphere;

Reference yield:

1-chloro-4-(trifluoromethoxy)benzene (461-81-4) → 4-chloro-2-nitro-1-(trifluoromethoxy)benzene (448-38-4) + 4-(trifluoromethoxy)-2-nitro-1-chlorobenzene (588-09-0)

Guidance literature:

With sulfuric acid; nitric acid; at 50 ℃; for 3h;

upstream raw materials:

1-chloro-4-(trifluoromethoxy)benzene

silver(I) trifluoromethoxide

4-Chloro-3-nitroaniline

Downstream raw materials:

4-chloro-2(-3)-nitrotrifluoro-methoxybenzene

Refernces

• 1、 -. "NITRATION". Page/Page column 36; 37; 47; 66-67; 38; 43; 50; 68. . Retrieved 2020/05/28.
• 2、 -. "Method for trifluoro methoxylation of arylamine". Paragraph 0086; 0087. . Retrieved 2018/10/11.