Ethyl 2-amino-6-methyl-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:Ethyl 2-amino-6-methyl-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:50626-53-4
Molecular Formula:C₁₉H₂₁F₃N₂O₄
Molecular Weight:398.382
Hs Code.:
DSSTox Substance ID:DTXSID70964862
Mol file:50626-53-4.mol

Synonyms:Ethyl 2-amino-6-methyl-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(2-(trifluoromethyl)phenyl)-, diethyl ester;50626-53-4;diethyl 2-amino-4-(2-(trifluoromethyl)phenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylate;SCHEMBL11688212;DTXSID70964862;C19H21F3N2O4;LSZZIXHPWSOXLE-UHFFFAOYSA-N;C19-H21-F3-N2-O4;diethyl 2-amino-6-methyl-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3,5-dicarboxylate;LS-131185

Suppliers and Price of Ethyl 2-amino-6-methyl-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Ethyl 2-amino-6-methyl-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Vapor Pressure:5.26E-10mmHg at 25°C
Boiling Point:496.7°Cat760mmHg
Flash Point:254.2°C
Density:1.266g/cm³
XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:7
Exact Mass:398.14534164
Heavy Atom Count:28
Complexity:685

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2C(F)(F)F)C(=O)OCC)N)C

Technology Process of Ethyl 2-amino-6-methyl-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate

There total 1 articles about Ethyl 2-amino-6-methyl-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50626-53-4
2-Amino-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Guidance literature:: entspr. 'Acetoessigester', entspr. 'Amidinoessigester';

Reference yield: 55.0%

: 103-71-9
phenyl isocyanate

: 50626-53-4
2-Amino-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

: 128164-85-2
1,4-Dihydro-2-methyl-6-(3-phenylureido)-4-<2-(trifluormethyl)phenyl>-3,5-pyridindicarbonsaeure-diethylester

Guidance literature:: In acetonitrile; for 3h; Heating;

Reference yield:

: 50626-53-4
2-Amino-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

: 128164-86-3
1,2,3,4,5,8-Hexahydro-7-methyl-2,4-dioxo-3-phenyl-5-<2-(trifluormethyl)phenyl>pyrido<2,3-d>pyrimidin-6-carbonsaeure-ethylester 1-Kaliumsalz

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / acetonitrile / 3 h / Heating

2: 68 percent / KOH / ethanol / 1 h / Heating

With potassium hydroxide; In ethanol; acetonitrile;