Technology Process of 2-Pentenoic acid, 5-hydroxy-3-methyl-5-phenyl-, ethyl ester, (2E,5R)-
There total 2 articles about 2-Pentenoic acid, 5-hydroxy-3-methyl-5-phenyl-, ethyl ester, (2E,5R)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: LDA; hexamethylphosphoramide / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 68 percent / hexamethylphosphoramide / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / -78 - 20 °C
2.1: (R,R)-N,N'-bis(phosphoramide)-N,N'-Me2-1,5-pentanediamine; SiCl4 / CH2Cl2 / 3 h / -78 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; tetrachlorosilane; (R,R)-N,N'-bis(phosphoramide)-N,N'-Me2-1,5-pentanediamine; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja047339w
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran; acetic acid;
at 0 ℃;
for 1h;
optical yield given as %de;
DOI:10.1021/ol800742d
- Guidance literature:
-
acetic anhydride; (2E,5R)-5-hydroxy-3-methyl-5-phenyl-2-pentenoic acid ethyl ester;
With
pyridine;
at 20 ℃;
for 1.5h;
With
ruthenium trichloride; sodium periodate;
In
dichloromethane; acetonitrile;
at 20 ℃;
for 2h;
DOI:10.1021/ja047339w
