[4-(Ethoxymethyl)-2,6-dimethoxyphenyl]boronic acid

Base Information

• Chemical Name: [4-(Ethoxymethyl)-2,6-dimethoxyphenyl]boronic acid
• CAS No.: 591249-50-2
• Molecular Formula: C11H17BO5
• Molecular Weight: 240.064
• DSSTox Substance ID: DTXSID70437046
• Wikidata: Q82252404
• Mol file: 591249-50-2.mol

Synonyms:591249-50-2;[4-(Ethoxymethyl)-2,6-dimethoxyphenyl]boronic acid;4-ethoxymethyl-2,6-dimethoxyphenylboronic acid;(4-(Ethoxymethyl)-2,6-dimethoxyphenyl)boronic acid;4-(ETHOXYMETHYL)-2,6-DIMETHOXYPHENYLBORONIC ACID;SCHEMBL1021545;DTXSID70437046;BCMKFWFNEMRLOO-UHFFFAOYSA-N;MFCD14525658;AS-48120;CS-0144220;4-ethyoxymethyl-2,6-dimetoxyphenylboronic acid;F18828;(4-(Ethoxymethyl)-2,6-dimethoxyphenyl)boronicacid;2,6-Dimethoxy-4-(ethoxymethyl)phenylboronic acid

Chemical Property of [4-(Ethoxymethyl)-2,6-dimethoxyphenyl]boronic acid

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 240.1169038
• Heavy Atom Count: 17
• Complexity: 200

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B(C1=C(C=C(C=C1OC)COCC)OC)(O)O

Technology Process of [4-(Ethoxymethyl)-2,6-dimethoxyphenyl]boronic acid

There total 1 articles about [4-(Ethoxymethyl)-2,6-dimethoxyphenyl]boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (4-(ethoxymethyl)-2,6-dimethoxyphenyl)boronic acid (591249-50-2)

Guidance literature:

Reference yield: 94.0%

(4-(ethoxymethyl)-2,6-dimethoxyphenyl)boronic acid (591249-50-2) + tert-butyl (3-bromo-6-methoxypyrazolo[5,1-b][1,3]thiazol-7-yl)carbamate (1190854-65-9) → tert-butyl {3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxypyrazolo[5,1-b][1,3]thiazol-7-yl}carbamate (1190854-66-0)

Guidance literature:

With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 90 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/jm300864p

Reference yield: 70.0%

(4-(ethoxymethyl)-2,6-dimethoxyphenyl)boronic acid (591249-50-2) + 7-bromo-N-(cyclopropylmethyl)-2-ethyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]pyrazolo[1,5-a]pyridin-3-amine (685886-48-0) → N-(cyclopropylmethyl)-7-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-2-ethyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]-pyrazolo[1,5-a]pyridin-3-amine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate; In 1,2-dimethoxyethane; water; at 90 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm300259r

Downstream raw materials:

tert-butyl {3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxypyrazolo[5,1-b][1,3]thiazol-7-yl}carbamate