3,5-bis(3-methoxyphenyl)-1H-1,2,4-triazole

Base Information

Chemical Name:3,5-bis(3-methoxyphenyl)-1H-1,2,4-triazole
CAS No.:59153-22-9
Molecular Formula:C16H15N3O2
Molecular Weight:281.314
Hs Code.:
DSSTox Substance ID:DTXSID90449803
Nikkaji Number:J1.711.615K

Synonyms:3,5-bis(3-methoxyphenyl)-1H-1,2,4-triazole;59153-22-9;1H-1,2,4-Triazole, 3,5-bis(3-methoxyphenyl)-;VAZVNPVVBGDFQN-UHFFFAOYSA-;DTXSID90449803;InChI=1/C16H15N3O2/c1-20-13-7-3-5-11(9-13)15-17-16(19-18-15)12-6-4-8-14(10-12)21-2/h3-10H,1-2H3,(H,17,18,19)

Suppliers and Price of 3,5-bis(3-methoxyphenyl)-1H-1,2,4-triazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-bis(3-methoxyphenyl)-1H-1,2,4-triazole

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:281.116426730
Heavy Atom Count:21
Complexity:329

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC(=C1)C2=NC(=NN2)C3=CC(=CC=C3)OC

Technology Process of 3,5-bis(3-methoxyphenyl)-1H-1,2,4-triazole

There total 4 articles about 3,5-bis(3-methoxyphenyl)-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: ethyl 3-methoxybenzenecarboximidoate hydrochloride

: 59153-22-9
3,5-bis(3-methoxyphenyl)-1H-1,2,4-triazole

Guidance literature:: With 1,10-Phenanthroline; ammonium carbonate; copper(II) bis(trifluoromethanesulfonate); sodium hydrogencarbonate; potassium hexacyanoferrate(III); In 1,2-dichloro-benzene; at 130 ℃; for 24h; Sealed tube;
DOI:10.1016/j.tet.2014.01.019

Reference yield: 54.0%

: 26113-44-0
3-methoxybenzene-1-carboximidamide hydrogenchloride

: 59153-22-9
3,5-bis(3-methoxyphenyl)-1H-1,2,4-triazole

Guidance literature:: With 1,10-Phenanthroline; copper(II) bis(trifluoromethanesulfonate); sodium hydrogencarbonate; potassium hexacyanoferrate(III); In 1,2-dichloro-benzene; at 130 ℃; for 24h; Sealed tube;
DOI:10.1016/j.tet.2014.01.019

Reference yield:

: 1527-89-5
3-methoxybenzonitrile

: 59153-22-9
3,5-bis(3-methoxyphenyl)-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: acetyl chloride / 24 h / 0 - 20 °C

2: sodium hydrogencarbonate; potassium hexacyanoferrate(III); 1,10-Phenanthroline; copper(II) bis(trifluoromethanesulfonate); ammonium carbonate / 1,2-dichloro-benzene / 24 h / 130 °C / Sealed tube

With 1,10-Phenanthroline; ammonium carbonate; copper(II) bis(trifluoromethanesulfonate); sodium hydrogencarbonate; acetyl chloride; potassium hexacyanoferrate(III); In 1,2-dichloro-benzene;
DOI:10.1016/j.tet.2014.01.019