Quinoline, 2-(2,2,2-trifluoroethyl)-

Base Information

• Chemical Name: Quinoline, 2-(2,2,2-trifluoroethyl)-
• CAS No.: 59321-22-1
• Molecular Formula: C₁₁H₈F₃N
• Molecular Weight: 211.186

Synonyms:

Chemical Property of Quinoline, 2-(2,2,2-trifluoroethyl)-

Chemical Property:

Purity/Quality:

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Technology Process of Quinoline, 2-(2,2,2-trifluoroethyl)-

There total 1 articles about Quinoline, 2-(2,2,2-trifluoroethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

difluoro((2-methylquinolin-1-ium-1-yl)oxy)(perfluoroethyl)borate + ((2-benzylquinolin-1-ium-1-yl)oxy)difluoro(trifluoromethyl)borate → 2-(2',2',2'-trifluoroethyl)quinoline (59321-22-1) + 2-(2,2,2-trifluoro-1-phenylethyl)quinoline + 2-(2,2,3,3,3-pentafluoropropyl)quinoline + 2-(2,2,3,3,3-pentafluoro-1-phenylpropyl)quinoline

Guidance literature:

With tetrabutyl ammonium fluoride; In ethyl acetate; acetonitrile; at 65 ℃; for 0.166667h; regioselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1002/anie.201505335

Reference yield:

2-(2',2',2'-trifluoroethyl)quinoline (59321-22-1) → (4,5-dimethyl-1-benzylimidazol-2-yl)(1,2-dihydroquinolin-2-ylidene)acetic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 2 h / -78 - 20 °C / Schlenk technique; Inert atmosphere

2: tetrahydrofuran / 20 h / 20 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; toluene;

DOI:10.1002/ejoc.201500072

Reference yield:

2-(2',2',2'-trifluoroethyl)quinoline (59321-22-1) → 4-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methoxy)-2-(2,2,2-trifluoroethyl)quinoline

Guidance literature:

Multi-step reaction with 6 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 25 °C / Inert atmosphere

2: trifluoroacetic acid; sodium nitrite / 0.5 h / 50 °C / Inert atmosphere

3: phosphorous acid trimethyl ester / dichloromethane / 5 h / 25 °C / Irradiation

4: trifluoroacetic acid; sulfuric acid / 3 h / 50 °C

5: caesium carbonate / acetone / 2 h / Reflux

6: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; sulfuric acid; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium nitrite; phosphorous acid trimethyl ester; In 1,4-dioxane; methanol; dichloromethane; chloroform; acetone;

DOI:10.1002/anie.201505335

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