1-Iodo-2,4-diMethyl-6-nitrobenzene

Base Information

• Chemical Name: 1-Iodo-2,4-diMethyl-6-nitrobenzene
• CAS No.: 593255-20-0
• Molecular Formula: C8H8INO2
• Molecular Weight: 277.062
• Hs Code.: 2904909090
• Mol file: 593255-20-0.mol

Synonyms:2-Iodo-1,5-dimethyl-3-nitrobenzene;

Chemical Property of 1-Iodo-2,4-diMethyl-6-nitrobenzene

Chemical Property:

• Melting Point: 102-107°C
• Boiling Point: 320.0±30.0 °C(Predicted)
• PSA: 45.82000
• Density: 1.777±0.06 g/cm3(Predicted)
• LogP: 3.33940
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

1-Iodo-2,4-dimethyl-6-nitrobenzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Iodo-2,4-diMethyl-6-nitrobenzene

There total 3 articles about 1-Iodo-2,4-diMethyl-6-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2,4-Dimethyl-6-nitroanilin (1635-84-3) → 2-iodo-3,5-dimethyl-1-nitrobenzene (593255-20-0)

Guidance literature:

2,4-Dimethyl-6-nitroanilin; With sulfuric acid; sodium nitrite; In acetic acid; at 15 - 75 ℃;

With urea; potassium iodide;

DOI:10.1016/S0957-4166(03)00217-9

Reference yield:

2,4-Xylidine (95-68-1) → 2-iodo-3,5-dimethyl-1-nitrobenzene (593255-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 86 percent / 96 percent HNO₃; Ac₂O / 1.17 h / 7 °C

2.1: NaNO₂; conc. H₂SO₄ / acetic acid / 15 - 75 °C

2.2: 69 percent / aq. KI; urea

With sulfuric acid; nitric acid; acetic anhydride; sodium nitrite; In acetic acid;

DOI:10.1016/S0957-4166(03)00217-9

Reference yield:

→ 2-iodo-3,5-dimethyl-1-nitrobenzene (593255-20-0)

Guidance literature:

With potassium iodide;

upstream raw materials:

2,4-Dimethyl-6-nitroanilin

2,4-Xylidine

Downstream raw materials:

1,5-dimethyl-2,3,4-trinitro-benzene

2,4-Dimethyl-6-nitroanilin

C₁₄H₁₅NO₄

Refernces

• 1、 Schmid, Rudolf,Cereghetti, Marco,Heiser, Bernd,Schoenholzer, Peter,Hansen, Hans-Juergen. "Axially Dissymmetric Bis(triaryl)phosphines in the Biphenyl Series: Synthesis of (6,6'-Dimethylbiphenyl-2,2'-diyl)bis(diphenylphosphine) ('BIPHEMP') and Analogues, and their Use in Rh(I)-Catalyzed Asymmetric Isomerisations of N,N-Diethylnerylamine". . p. 897 - 930. Retrieved 2007/10/02.