1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-11,15-dimethyl-13-methylene-17-(2,2,2-trifluoroethoxy)-2-(2,4, 6-trimethylphenyl)-, (2R,5S,10S,11E,15S,16Z)-

Base Information

Chemical Name:1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-11,15-dimethyl-13-methylene-17-(2,2,2-trifluoroethoxy)-2-(2,4, 6-trimethylphenyl)-, (2R,5S,10S,11E,15S,16Z)-
CAS No.:594854-88-3
Molecular Formula:C₃₁H₃₉F₃O₆
Molecular Weight:564.642
Hs Code.:

1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione,
10-ethyl-11,15-dimethyl-13-methylene-17-(2,2,2-trifluoroethoxy)-2-(2,4,
6-trimethylphenyl)-, (2R,5S,10S,11E,15S,16Z)-

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Chemical Property of 1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-11,15-dimethyl-13-methylene-17-(2,2,2-trifluoroethoxy)-2-(2,4, 6-trimethylphenyl)-, (2R,5S,10S,11E,15S,16Z)-

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Technology Process of 1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-11,15-dimethyl-13-methylene-17-(2,2,2-trifluoroethoxy)-2-(2,4, 6-trimethylphenyl)-, (2R,5S,10S,11E,15S,16Z)-

There total 7 articles about 1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-11,15-dimethyl-13-methylene-17-(2,2,2-trifluoroethoxy)-2-(2,4, 6-trimethylphenyl)-, (2R,5S,10S,11E,15S,16Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 594854-87-2
(2R,4S)-4-[(2Z,7E)-(4S,9S)-9-Acetoxy-4,8-dimethyl-6-methylene-2-(2,2,2-trifluoro-ethoxy)-undeca-2,7-dienyl]-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxolane-4-carboxylic acid methyl ester

: 594854-88-3
(11E,16Z)-(2R,5S,10S,15S)-10-Ethyl-11,15-dimethyl-13-methylene-17-(2,2,2-trifluoro-ethoxy)-2-(2,4,6-trimethyl-phenyl)-1,3,9-trioxa-spiro[4.13]octadeca-11,16-diene-6,8-dione

Guidance literature:: With lithium hexamethyldisilazane; In N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/j.bmcl.2003.09.072

Reference yield:

: 241823-00-7
(E)-(2S,7S)-2,6-Dimethyl-4-methylene-7-(2-trimethylsilanyl-ethoxymethoxy)-non-5-enal

: 594854-88-3
(11E,16Z)-(2R,5S,10S,15S)-10-Ethyl-11,15-dimethyl-13-methylene-17-(2,2,2-trifluoro-ethoxy)-2-(2,4,6-trimethyl-phenyl)-1,3,9-trioxa-spiro[4.13]octadeca-11,16-diene-6,8-dione

Guidance literature:: Multi-step reaction with 9 steps

1: LHMDS

2: methanesulfonyl chloride; Et₃N; 1,8-diazabicyclo[5.4.0]undec-7-ene

3: diisobutylaluminum hydride

4: I₂; PPh₃; imidazole

5: LHMDS / hexamethylphosphoric acid triamide

6: tetraethylammonium fluoride

7: DMAP; pyridine

8: LHMDS / hexamethylphosphoric acid triamide

With pyridine; 1H-imidazole; dmap; iodine; diisobutylaluminium hydride; tetraethylammonium fluoride; methanesulfonyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; In N,N,N,N,N,N-hexamethylphosphoric triamide; 9: Macro-Dieckmann cyclization;
DOI:10.1016/j.bmcl.2003.09.072

Reference yield:

: (2Z,7E)-(4S,9S)-4,8-Dimethyl-6-methylene-2-(2,2,2-trifluoro-ethoxy)-9-(2-trimethylsilanyl-ethoxymethoxy)-undeca-2,7-dien-1-ol

: 594854-88-3
(11E,16Z)-(2R,5S,10S,15S)-10-Ethyl-11,15-dimethyl-13-methylene-17-(2,2,2-trifluoro-ethoxy)-2-(2,4,6-trimethyl-phenyl)-1,3,9-trioxa-spiro[4.13]octadeca-11,16-diene-6,8-dione

Guidance literature:: Multi-step reaction with 6 steps

1: I₂; PPh₃; imidazole

2: LHMDS / hexamethylphosphoric acid triamide

3: tetraethylammonium fluoride

4: DMAP; pyridine

5: LHMDS / hexamethylphosphoric acid triamide

With pyridine; 1H-imidazole; dmap; iodine; tetraethylammonium fluoride; triphenylphosphine; lithium hexamethyldisilazane; In N,N,N,N,N,N-hexamethylphosphoric triamide; 6: Macro-Dieckmann cyclization;
DOI:10.1016/j.bmcl.2003.09.072