1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-11,15-dimethyl-13-methylene-17-(methylthio)-2-(2,4,6-trimethyl phenyl)-, (2R,5S,10S,11E,15S,16Z)-

Base Information

Chemical Name:1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-11,15-dimethyl-13-methylene-17-(methylthio)-2-(2,4,6-trimethyl phenyl)-, (2R,5S,10S,11E,15S,16Z)-
CAS No.:594855-36-4
Molecular Formula:C₃₀H₄₀O₅S
Molecular Weight:512.711
Hs Code.:

1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione,
10-ethyl-11,15-dimethyl-13-methylene-17-(methylthio)-2-(2,4,6-trimethyl
phenyl)-, (2R,5S,10S,11E,15S,16Z)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-11,15-dimethyl-13-methylene-17-(methylthio)-2-(2,4,6-trimethyl phenyl)-, (2R,5S,10S,11E,15S,16Z)-

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Technology Process of 1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-11,15-dimethyl-13-methylene-17-(methylthio)-2-(2,4,6-trimethyl phenyl)-, (2R,5S,10S,11E,15S,16Z)-

There total 6 articles about 1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-11,15-dimethyl-13-methylene-17-(methylthio)-2-(2,4,6-trimethyl phenyl)-, (2R,5S,10S,11E,15S,16Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 594855-35-3
(2R,4S)-4-((2Z,7E)-(4S,9S)-9-Acetoxy-4,8-dimethyl-6-methylene-2-methylsulfanyl-undeca-2,7-dienyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxolane-4-carboxylic acid methyl ester

: 594855-36-4
(11E,16Z)-(2R,5S,10S,15S)-10-Ethyl-11,15-dimethyl-13-methylene-17-methylsulfanyl-2-(2,4,6-trimethyl-phenyl)-1,3,9-trioxa-spiro[4.13]octadeca-11,16-diene-6,8-dione

Guidance literature:: With lithium hexamethyldisilazane; In N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/j.bmcl.2003.09.072

Reference yield:

: 666715-13-5
(2Z,7E)-(4S,9S)-4,8-Dimethyl-6-methylene-2-methylsulfanyl-9-(2-trimethylsilanyl-ethoxymethoxy)-undeca-2,7-dien-1-ol

: 594855-36-4
(11E,16Z)-(2R,5S,10S,15S)-10-Ethyl-11,15-dimethyl-13-methylene-17-methylsulfanyl-2-(2,4,6-trimethyl-phenyl)-1,3,9-trioxa-spiro[4.13]octadeca-11,16-diene-6,8-dione

Guidance literature:: Multi-step reaction with 6 steps

1: I₂; PPh₃; imidazole

2: LHMDS / hexamethylphosphoric acid triamide

3: tetraethylammonium fluoride

4: DMAP; pyridine

5: LHMDS / hexamethylphosphoric acid triamide

With pyridine; 1H-imidazole; dmap; iodine; tetraethylammonium fluoride; triphenylphosphine; lithium hexamethyldisilazane; In N,N,N,N,N,N-hexamethylphosphoric triamide; 6: Macro-Dieckmann cyclization;
DOI:10.1016/j.bmcl.2003.09.072

Reference yield:

: [2-((2E,7Z)-(1S,6S)-1-Ethyl-9-iodo-2,6-dimethyl-4-methylene-8-methylsulfanyl-nona-2,7-dienyloxymethoxy)-ethyl]-trimethyl-silane

: 594855-36-4
(11E,16Z)-(2R,5S,10S,15S)-10-Ethyl-11,15-dimethyl-13-methylene-17-methylsulfanyl-2-(2,4,6-trimethyl-phenyl)-1,3,9-trioxa-spiro[4.13]octadeca-11,16-diene-6,8-dione

Guidance literature:: Multi-step reaction with 5 steps

1: LHMDS / hexamethylphosphoric acid triamide

2: tetraethylammonium fluoride

3: DMAP; pyridine

4: LHMDS / hexamethylphosphoric acid triamide

With pyridine; dmap; tetraethylammonium fluoride; lithium hexamethyldisilazane; In N,N,N,N,N,N-hexamethylphosphoric triamide; 5: Macro-Dieckmann cyclization;
DOI:10.1016/j.bmcl.2003.09.072